Optical Clearing of the Skin in Conjunction With Laser Treatments

The research hypothesis is that topical application of a mixture of pre-polymers of polypropylene glycol and polyethylene glycol (an optical clearing agent) will reduce skin light scattering, increasing the amount of light reaching the target for diagnostic as well as therapeutic purposes.

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Key information

Conditions

Port Wine Stain Acne Acne Vulgaris Acneiform Eruptions Cicatrix Congenital Abnormalities Congenital, Hereditary, and Neonatal Diseases and Abnormalities Fibrosis Hair Diseases Hypertrichosis Neoplasms Neoplasms by Histologic Type Nevi and Melanomas Nevus Nevus of Ota Nevus, Pigmented Pathologic Processes Pathological Conditions, Signs and Symptoms Port-Wine Stain Scars Sebaceous Gland Diseases Skin Abnormalities Skin Diseases Skin and Connective Tissue Diseases Tattoos

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 1

Primary location

Beckman Laser Institute Medical and Surgical Clinic

Irvine, California, 92612, United States

About this study

The researchers expect that application of the optical clearing agent for treatment of benign vascular lesions, tattoos, nevus of Ota, hypertrichosis, scars, acne and sebaceous hyperplasia will result in

decreased reflectance of the predominant color from the surface of skin (decreased red light scattering in case of benign vascular lesions, etc) as compared to the control group.
greater Optical Coherence Tomography a non-invasive light based imaging method imaging depth as compared to the control group.
greater improvement in the treatment outcome (decrease in the erythema index following laser treatment of vascular lesions as compared to the laser alone group; improved lightening of the tattoo or nevus of Ota as compared to the laser treatment alone group; significant decrease in hair re-growth as compared to laser treatment alone in patients seeking hair removal; greater improvement of scars, acne and sebaceous hyperplasia).

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Adult 18 years and older
Lesion diagnoses in an area measuring 3 cm2 or more on any body site
Apparent good health

Exclusion criteria

Pregnant women
History of cutaneous photosensitivity
History of photodermatoses

Treatment and study plan

Optical Clearing

Device

Optical Clearing

Primary outcomes

Outcome measure is to evaluate the optical clearing effects of the combination mixture of pre-polymers of polypropylene glycol and polyethylene glycol.

Time frame: 8 weeks

Sponsors and collaborators

Lead sponsor

University of California, Irvine

Other

Collaborators

Beckman Laser Institute University of California Irvine

Registry information

Important dates

Study start: 2004
Primary completion: 2008
Study completion: 2008
First posted: Dec 27, 2007
Registry last updated: Oct 20, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed