Recruiting

NCT Number: NCT06203106

NYSCF Scientific Discovery Biobank

The New York Stem Cell Foundation (NYSCF) Research Institute is performing this research to accelerate diverse disease research using cells from the body (such as skin or blood cells) to make stem cells and other types of cells, conduct research on the samples, perform genetic testing, and store the samples for future use.

Through this research, researchers hope to identify future treatments or even cures for the major diseases of our time.

Recruiting

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Key information

Conditions

ALS Adnexal Diseases Alzheimer Disease Alzheimer Disease, Early Onset Alzheimer Disease, Late Onset Amyotrophic Lateral Sclerosis Autoimmune Diseases Autoimmune Diseases of the Nervous System Autonomic Nervous System Diseases Basal Ganglia Diseases Batten Disease Brain Diseases Central Nervous System Diseases Cervical Cancer Chorea Cognition Disorders Congenital, Hereditary, and Neonatal Diseases and Abnormalities Corticobasal Degeneration Cranial Nerve Diseases Dementia Demyelinating Autoimmune Diseases, CNS Demyelinating Diseases Diabetes Diabetes Mellitus Diabetes Mellitus, Type 1 Diabetes Mellitus, Type 2 Dyskinesias Endocrine Gland Neoplasms Endocrine System Diseases Eye Diseases Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Frontotemporal Dementia Frontotemporal Lobar Degeneration Genetic Diseases, Inborn Genital Diseases Genital Diseases, Female Genital Neoplasms, Female Glucose Metabolism Disorders Gonadal Disorders Heredodegenerative Disorders, Nervous System Huntington Disease INAD Immune System Diseases Lewy Body Disease Lipid Metabolism Disorders Lipid Metabolism, Inborn Errors Lipidoses Macular Degeneration Mental Disorders Metabolic Diseases Metabolism, Inborn Errors Motor Neuron Disease Movement Disorders Multiple Sclerosis Multiple System Atrophy Neoplasms Neoplasms by Site Nervous System Diseases Neurocognitive Disorders Neurodegenerative Diseases Neurologic Manifestations Neuromuscular Diseases Neuronal Ceroid-Lipofuscinoses Nutritional and Metabolic Diseases Ocular Motility Disorders Ophthalmoplegia Ovarian Cancer Ovarian Diseases Ovarian Neoplasms PTSD Paralysis Parkinson Disease Parkinson's Disease and Parkinsonism Parkinsonian Disorders Pathological Conditions, Signs and Symptoms Post Traumatic Stress Disorder Primary Dysautonomias Progressive Supranuclear Palsy Proteostasis Deficiencies Retinal Degeneration Retinal Diseases Signs and Symptoms Spinal Cord Diseases Stress Disorders, Post-Traumatic Stress Disorders, Traumatic Supranuclear Palsy, Progressive Synucleinopathies TDP-43 Proteinopathies Tauopathies Trauma and Stressor Related Disorders Urogenital Diseases Urogenital Neoplasms Uterine Cancer Uterine Cervical Diseases Uterine Cervical Neoplasms Uterine Diseases Uterine Neoplasms Vaginal Cancer Vaginal Diseases Vaginal Neoplasms Vulvar Cancer Vulvar Diseases Vulvar Neoplasms

Age range

30 day and older

Sex eligibility

All sexes

Study type

Observational

Primary location

New York Stem Cell Foundation Research Institute

New York, 10019, United States

Location status: Recruiting

Location contact

Clinical Research Office

CONTACT

[email protected]

212-927-1801

Laura Andres-Martin, PhD

PRINCIPAL_INVESTIGATOR

About this study

Researchers at the New York Stem Cell Foundation (NYSCF) Research Institute study diverse diseases, conditions, and traits by creating stem cells from biological samples. These "pluripotent" stem cells can become any cell in the human body, including cells that may be difficult, invasive, or impossible to obtain directly.

Additionally, researchers perform genetic testing to learn more about DNA, a material in most cells that contains instructions for the body's development and functions (such as traits like eye color and risk of certain diseases). A piece of DNA that determines the specific role of a cell is called a "gene." If the instructions in a gene are abnormal, this can lead to disease.

Participation in the study involves: (1) completion of health questionnaires, (2) providing a skin and/or blood sample from which stem cells may be created, (3) collection of a saliva sample for genetic analysis, and (4) possible future followup to provide additional information or learn about other research studies.

This study is not a clinical trial.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Age 30 days or older.
Diagnosis and/or medical history of a condition, disease, genetic background, or trait of interest or healthy control.
Adults with decisional capacity must provide written informed consent unless physical limitations preclude signing.
Adults without decisional capacity to consent must a have diagnosis of Amyotrophic Lateral Sclerosis (ALS), Alzheimer's Disease and Related Dementias (AD/ADRD); Batten Disease, Corticobasal Degeneration (CBD), Dementia, Frontotemporal Dementia (FTD), Huntington Disease, Lewy Body Disease, Multiple Sclerosis, Multiple System Atrophy, Parkinson's Disease (PD), Parkinsonism, and/or Progressive Supranuclear Palsy, and must provide assent; a legally authorized representative (LAR) must also provide written informed consent.
Minors undergoing skin collection for research purposes must have a condition, disease, genetic background, or trait of interest and parental/guardian consent.
Minors undergoing blood, and/or saliva collection for research purposes may have a condition, disease, genetic background, or trait of interest or serve as a healthy control and must have an available parent/guardian to provide consent.
Minors transferring biological samples and associated data from a procedure outside of the research may have a condition, disease, genetic background, or trait of interest or serve as a healthy control and must have an available parent/guardian to provide consent.

Exclusion criteria

Wards of the state.
For prospective skin samples: history of keloid formation, coagulation disorder, or allergy to the anesthetic.
For prospective blood samples: history of coagulation disorder.
For all prospective sample collections: 1) Subjects who refuse to adhere to NYSCF's and/or a collection site's safety protocol(s) will be excluded; 2) Subjects with an AIDS diagnosis and CD4 count of less than 200 cells per microliter (mcL) of blood will be excluded due to increased risk of infection.

Treatment and study plan

Biological sample collection

Other

Skin biopsy (2-3mm) and/or blood (up to 50 mL); saliva; excess/ leftover biospecimens that were (or will be) collected for other purposes (e.g., medical procedure).

Primary outcomes

Biobank

Time frame: Baseline

Establishment of a diverse repository of biological samples, stem cell lines, derivatives, and associated information to support investigations into the biology, etiology, manifestations, progression, risk factors, genetic underpinnings, and treatment of diseases, conditions, and traits.

Study contacts

Contact information is provided by the study sponsor or research team.

Clinical Research Office

CONTACT

[email protected]

212-927-1801

Sponsors and collaborators

Lead sponsor

New York Stem Cell Foundation Research Institute

Other

Registry information

Important dates

Study start: 2022
Primary completion: 2045
Study completion: 2045
First posted: Jan 12, 2024
Registry last updated: Mar 3, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Recruiting