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Completed

NCT Number: NCT02150005

Non-surgical Periodontal Treatment on Hemogram, Lipid and Glycemic Profiles in Patients With Coronariopathies

Objective: The aim of this study was to examine the effects of non-surgical periodontal treatment on the hemogram, glycemic and lipid profiles in cardiopathic patients with an indication for surgical revascularization.

Materials and Methods: Twenty-two patients with chronic periodontitis, over 35 years of age (mean age 59.45 years) randomly assigned into 2 groups were evaluated. Test group (n=11), received periodontal treatment before the surgical procedure, and control group (n=11), did not received periodontal treatment prior to surgery.

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Key information

Conditions

Periodontitis Cardiovascular Diseases Coronariopathy Mouth Diseases Periodontal Diseases Stomatognathic Diseases

Age range

35 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Undergoing cardiovascular treatment;
  • Eight viable teeth in the oral cavity;
  • Four periodontal sites with periodontal probing depths ≥5mm in different teeth.

Exclusion criteria

-

Treatment and study plan

Periodontal Treatment

Procedure

Primary outcomes

  1. Reduction in probing depth in sites with PPD>3mm

    Time frame: Baseline and 90 days after the initial exam

    Reduction of 11.4% in probing depth in sites with Periodontal Probing Depth>3mm

  2. Reduction in probing depth in sites with PPD>5mm

    Time frame: Baseline and 90 days after the initial exam

    Reduction of 6.3% in probing depth in sites with Periodontal Probing Depth>5mm

  3. Reduction in probing depth in sites with CAL>3mm

    Time frame: Baseline and 90 days after the initial exam

    Reduction of 4.6% in probing depth in sites with Clinical Attachment Level >3mm.

  4. Reduction in probing depth in sites with CAL >5mm

    Time frame: Baseline and 90 days after the initial exam

    Reduction of 3.6% in probing depth in sites with Clinical Attachment Level >5mm.

  5. Leukocyte count

    Time frame: Baseline and 90 days after the initial exam

    Non-significant reduction of leukocyte count in the test group. Mean difference of 74.6 m/mcL.

  6. Glucose

    Time frame: Baseline and 90 days after the initial exam

    Glucose showed a non-significant increase in the test group. Mean difference of 24.2 mg/dL.

  7. Hemocyte

    Time frame: Baseline and 90 days after initial exam

    Hemocyte presented a non-significant reduction in the test group. Mean difference 0.39 m/mcL

  8. Hemoglobin

    Time frame: Baseline and 90 days after initial exam

    Non-significant reduction in test group. Mean difference of 0.2 g/dL

  9. Total Cholesterol

    Time frame: Baseline and 90 days after initial exam

    Significant reduction in the test group. Mean reduction of 27.4 mg/dL.

  10. High density lipid

    Time frame: Baseline and 90 days after initial exam

    Significant reduction in test group. Mean difference of 8.2 mg/dL.

  11. Low density lipid

    Time frame: Baseline and 90 days after initial exam

    Non-significant reduction in test group. Mean difference of 8.9 mg/dL.

Sponsors and collaborators

Lead sponsor

Universidade Veiga de Almeida

Other

Collaborators

  • Rio de Janeiro State Research Supporting Foundation (FAPERJ)

Registry information

Official study title

Effects of Non-surgical Periodontal Treatment on Hemogram, Lipid and Glycemic Profiles of Patients With an Indication for Surgical Coronary Revascularization

Important dates

Study start
2009
Primary completion
2010
First posted
May 29, 2014
Registry last updated
May 29, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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