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Completed

NCT Number: NCT03459027

Nitrate Supplementation and Muscle Blood Flow

The main purpose of this study is to evaluate the effects of an acute dose of dietary nitrate in the form of beetroot juice on skeletal muscle blood flow in response to dynamic knee extension exercise in healthy older adults. All subjects will receive active (rich in dietary nitrate) or placebo (devoid of nitrate) supplementation.

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Key information

Conditions

Vasodilation Active Hyperemia Aging Aneurysm Blood Pressure Cardiovascular Diseases Hyperemia Vascular Diseases

Age range

60 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Medical Education Building

Iowa City, Iowa, 52242, United States

About this study

Dietary nitrate (beetroot juice) is reduced to nitrite and nitric oxide within the digestive system of humans. Nitric oxide exerts potent vasodilator effects, which have been shown to reduce blood pressure and enhance exercise economy in humans. This pressure reducing effect may have implications within the regulation of blood flow during dynamic exercise in older adults.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy older adults 60-80 years of age

Exclusion criteria

  • Hypertension,
  • Smoking,
  • Heart disease,
  • Diabetes,
  • Body mass index (BMI) ≥ 30 kg/m2,
  • Autonomic disorders and other conditions that may alter blood pressure or vascular function
  • Medications that might normally alter blood pressure or vascular function.
  • Older women taking hormone replacement therapy medications.

Treatment and study plan

Super Beets

Dietary Supplement

Nitrate rich beetroot powder (10g) acutely

Beetroot powder

Dietary Supplement

Nitrate devoid beetroot powder (10g) acutely

Primary outcomes

  1. Change in Skeletal Muscle Blood Flow within the Leg via Doppler Ultrasound

    Time frame: Pre and 2 hours post acute ingestion of dietary nitrate and placebo with at least 5 days of separation between visits.

    Leg blood flow via Doppler ultrasound examined during dynamic knee extension exercise. Change in blood flow in response to dynamic knee exercise will be measured to examine the influence of dietary nitrate.

Sponsors and collaborators

Lead sponsor

University of Iowa

Other

Registry information

Official study title

Nitric Oxide Bioavailability and Dynamics of Blood Flow and Vasodilation With Age

Important dates

Study start
2017
Primary completion
2018
Study completion
2018
First posted
Mar 8, 2018
Registry last updated
Jan 9, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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