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NCT Number: NCT06417177

Impact of Early Aging and Menopause on the Vascular Responses to Hypoxia

The purpose of this study is to examine hypoxic vasodilation and the role of beta-adrenergic receptors in younger premenopausal, perimenopausal, and older postmenopausal women.

Recruiting

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Key information

Conditions

Aging Aneurysm Cardiovascular Diseases Hypoxia Menopause Pathological Conditions, Signs and Symptoms Signs and Symptoms Signs and Symptoms, Respiratory Vascular Diseases Vasodilation

Age range

18 year–70 year

Sex eligibility

Female

Study type

Interventional

Phase

Early Phase 1

Primary location

University of Missouri-Columbia

Columbia, Missouri, 65211, United States

Location status: Recruiting

Location contact

Jacqueline K Limberg, Ph.D.

CONTACT

[email protected]

573-882-2420

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Female assigned at birth
  • Pre, peri- or post-menopausal
  • Healthy weight (BMI ≥18 and ≤30 kg/m2)

Exclusion criteria

  • Male (assigned at birth)
  • Pregnancy, breastfeeding
  • Use of hormone replacement therapies
  • Hysterectomy
  • Body mass index >30 kg/m2
  • Diagnosed sleep apnea
  • Current smoking/Nicotine/Drug use
  • Nerve/neurologic disease
  • Cardiovascular, hepatic, renal, respiratory disease
  • Blood pressure ≥140/90 mmHg
  • Diabetes, Polycystic ovarian syndrome
  • Communication barriers
  • Prescription medications
  • Malignant cancer

Treatment and study plan

Placebo

Drug

Participants will receive a placebo in pill form.

Propranolol

Drug

Participants will receive oral propranolol (1 mg/kg).

Gemtesa

Drug

Participants will receive oral gemtesa (75 mg).

Primary outcomes

  1. Forearm blood flow

    Time frame: Change from baseline to 5 minutes.

    Blood flow in the forearm measured with venous occlusion plethysmography.

Study contacts

Contact information is provided by the study sponsor or research team.

Jacqueline Limberg

CONTACT

[email protected]

573-882-2544

Sponsors and collaborators

Lead sponsor

University of Missouri-Columbia

Other

Registry information

Important dates

Study start
2024
Primary completion
2026
Study completion
2026
First posted
May 16, 2024
Registry last updated
Sep 9, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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