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Completed

NCT Number: NCT05337527

Neuromuscular Responses to Acute Beetroot Ingestion in Women Older Adults

Beetroot juice supplementation has shown the capacity for provoking different physiological effects (e.g. vasodilation and muscle contraction increments). However, the effects of beetroot juice ingestion on neuromuscular performance in women older adults are barely studied. In this randomized placebo-controlled study, we investigated the effects of beetroot acute supplementation in improving neuromuscular performance in women older adults

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Key information

Age range

65 year–80 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Universidad Francisco de Vitoria

Pozuelo de Alarcón, Madrid, 28223, Spain

About this study

Beetroot juice supplementation has shown the capacity for provoking different physiological effects that could affect human performance (e.g. vasodilation and muscle contraction increments). Although this dietary supplement has been commonly used for improving sports performance in recreational or professional athletes, the scientific literature in older adults is scarce. Thus, in our knowledge, no previous studies have analyzed the side effects associated to ingestion in this population group. In this randomized placebo-controlled study, we investigated the effects of beetroot acute supplementation in improving neuromuscular performance and side effects associated with ingestion in women older adults.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Women >65 or <85 years of age.
  • In good health, as determined by the investigator's review of history.

Exclusion criteria

(based in previous studies on this topic (doi: 10.1093/gerona/glaa311).

Men and women <65 or >85 years of age Unable to provide informed consent Current smokers Significant orthopedic limitations or other contraindications to strenuous exercise Those taking proton pump inhibitors, antacids, xanthine oxidase inhibitors, or on hormone replacement therapy Those taking anti-coagulants or on anti-platelet therapy History of neuromuscular disease (e.g., cervical spondylotic radiculomyelpathy, lumbar spondylosis, amyotrophic lateral sclerosis, Guillain-Barré syndrome, and acquired demyelinating polyneuropathies) Cardiovascular disease (e.g., > stage I hypertension, heart failure, myocardial infarction/ischemia significant myocardial or pericardial diseases (e.g. amyloidosis, constriction), Moderate or severe valvular disease, renal disease, liver disease, or anemia

Treatment and study plan

Beetroot juice

Dietary Supplement

Acute effects of beetroot juice or placebo juice ingestion

Primary outcomes

  1. Changes in maximal isometric handgrip strength (N)

    Time frame: 1-week

    Using a dynamometer and measuring dominant/ non-dominant side

  2. Changes in 6-m gait speed test

    Time frame: 1-week

    Using a photocell timing gates (seconds)

  3. Changes in Time Up and Go test

    Time frame: 1-week

    Using a photocell timing gates (seconds)

  4. Changes in Sit and Stand Test

    Time frame: 1-week

    Using Power Frail APP

  5. 6-Minute Walk Test

    Time frame: 1-week

Secondary outcomes

  1. Rate of perception effort (RPE)

    Time frame: 1-week

    Using a validated scale (1-10 points)

  2. Side effects questionnarie

    Time frame: 1-week

    Using a side-effects questionnarie (YES/NO scale)

Sponsors and collaborators

Lead sponsor

Universidad Francisco de Vitoria

Other

Registry information

Official study title

Neuromuscular Responses to Acute Beetroot Ingestion in Women Older Adults. Performance and Side Effects

Acronym: BEET_ELDERLY

Important dates

Study start
2022
Primary completion
2022
Study completion
2022
First posted
Apr 20, 2022
Registry last updated
May 9, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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