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Completed

NCT Number: NCT06613542

Effects Of Daily Taurine Intake For 6 Months On Biological Age and Body Metabolism Indicators As Well As Physical Fitness In 55-75-year-old Women And Men

The goal of this clinical trial is to investigate the effect of taking 4 grams of taurine by older adults on aging processes over a period of 6 months. It will also check for effects of taurine on participant's physical fitness, metabolic and cognitive functions. The main question it aims to answer is:

• Does a supplementation with 4 g of taurine daily over a period of 6 months slow down biological aging in humans? Researchers will compare supplementation with taurine to a placebo (a look-alike substance that contains no drug) to reliably determine whether taurine has an effect.

Participants will:

* Take 4g of taurine or a placebo every day for 6 months * Visit the study site 4 times for checkups and tests: for a screening visit, at the beginning of the intervention, after 8 and 24 weeks

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Key information

Conditions

Taurine Aging, Biological Anti-Aging Behavior DNA Methylation Dietary Supplement Longevity Metabolic Health Motor Activity Physical Activity Sport

Age range

55 year–75 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Institute for Nutritional Medicine of Technical University of Munich

Munich, 80992, Germany

About this study

Measurements performed during study visits:

  • Biological age estimate via proteome analysis
  • Organ age estimates (proteomics)
  • DNA methylation
  • Inflammatory biomarkers (CRP, cytokines)
  • Metabolic variables: fasting blood glucose, insulin, HOMA-IR, HbA1c, lipids, BMI
  • Physical fitness (hand grip strength, leg extensor strength, PWC130)
  • Resting energy expenditure
  • Cognitive function via questionnaire
  • Quality of life
  • Heart rate variability
  • Physical activity, nutrition

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • women or men
  • Age 55 - 75
  • BMI 22 - 30 kg/m²
  • written consent

Exclusion criteria

  • Acute or chronic inflammation (e.g. flu infection)
  • Severe chronic illness (e.g., Type 1 or Type 2 diabetes mellitus, COPD, renal insufficiency)
  • Myocardial infarction or stroke in the previous 6 months
  • Psychiatric disorder, including depression or dementia
  • Weight change of ≥ 5 kg in the last 6 months

Treatment and study plan

4g of taurine daily

Dietary Supplement

Intervention group (4g of taurine/day): 2g of taurine (4 capsules, 500mg each) in the morning and 2g of taurine (4 capsules, 500mg each) in the evening for 6 months

Placebo

Dietary Supplement

Controll group (4g of placebo/day): 2g of placebo (4 capsules, 500mg each) in the morning and 2g of placebo (4 capsules, 500mg each) in the evening for 6 months

Primary outcomes

  1. Change From Baseline in Biological Age At 6 Months (Proteome Analysis)

    Time frame: pre-intervention (at time point 0) and post-intervention (at 24 weeks)

    The primary objective of the study is to answer the following research question:

    Does a 6-month supplementation with 4g of taurine daily slow down biological aging in humans?

    Biological age will be determined using a plasma proteome analysis and established machine learning models based on plasma and urine samples. This will also include an analysis of organ-specific aging.

  2. Change From Baseline in Biological Age At 6 Months (DNA Methylation)

    Time frame: pre-intervention (at time point 0) and post-intervention (at 24 weeks)

    The primary objective of the study is to answer the following research question:

    Does a 6-month supplementation with 4g of taurine daily slow down biological aging in humans?

    Biological age will be estimated by assessing DNA methylation patterns (epigenetic clock) from plasma, urine, and oral mucosa samples.

Secondary outcomes

  1. Change From Baseline In Cognitive Functions at 6 Months

    Time frame: pre-intervention (at time point 0) and post-intervention (after 24 weeks)

    Does a 6-month supplementation with 4 g of taurine daily influence parameters of mental health?

    Methods of measurement: MoCA (Montreal Cognitive Assessment)

  2. Change From Baseline In Cardiometabolic Risk Profile at 6 Months

    Time frame: pre-intervention (at time point 0) and post-intervention (at 24 weeks)

    Does a 6-month supplementation with 4 g of taurine daily alter the cardiometabolic risk profile?

    Measurement: fasting blood glucose in mg/dL

  3. Change From Baseline In Cardiometabolic Risk Profile at 6 Months

    Time frame: pre-intervention (at time point 0) and post-intervention (at 24 weeks)

    Does a 6-month supplementation with 4 g of taurine daily alter the cardiometabolic risk profile?

    Measurement: Body-Mass-Index determined by participants weight in kilograms divided by height in metres squared.

  4. Change From Baseline In Cardiometabolic Risk Profile at 6 Months

    Time frame: pre-intervention (at time point 0) and post-intervention (at 24 weeks)

    Does a 6-month supplementation with 4 g of taurine daily alter the cardiometabolic risk profile?

    Measurement: blood pressure in mmHg

  5. Change From Baseline In Cardiometabolic Risk Profile at 6 Months

    Time frame: pre-intervention (at time point 0) and post-intervention (at 24 weeks)

    Does a 6-month supplementation with 4 g of taurine daily alter the cardiometabolic risk profile?

    Measurement: total cholesterol in mg/dl

  6. Change From Baseline In Cardiometabolic Risk Profile at 6 Months

    Time frame: pre-intervention (at time point 0) and post-intervention (at 24 weeks)

    Does a 6-month supplementation with 4 g of taurine daily alter the cardiometabolic risk profile?

    Measurement: LDL-cholesterol in mg/dL

  7. Change From Baseline In Cardiometabolic Risk Profile at 6 Months

    Time frame: pre-intervention (at time point 0) and post-intervention (at 24 weeks)

    Does a 6-month supplementation with 4 g of taurine daily alter the cardiometabolic risk profile?

    Measurement: HDL-cholesterol in mg/dL

  8. Change From Baseline In Cardiometabolic Risk Profile at 6 Months

    Time frame: pre-intervention (at time point 0) and post-intervention (at 24 weeks)

    Does a 6-month supplementation with 4 g of taurine daily alter the cardiometabolic risk profile?

    Measurement: C-reactive protein in mg/l

  9. Change From Baseline In Cardiometabolic Risk Profile at 6 Months

    Time frame: pre-intervention (at time point 0) and post-intervention (at 24 weeks)

    Does a 6-month supplementation with 4 g of taurine daily alter the cardiometabolic risk profile?

    Measurement: fasting insulin in pmol/l

  10. Change From Baseline In Handgrip Strength (kg) at 6 Months

    Time frame: pre-intervention (at time point 0) and post-intervention (at 24 weeks)

    Measurement of handgrip strength in kilograms and Newtons in the dominant hand using Jamar Hydraulic Hand Dynamometer.

  11. Change From Baseline In Physical Working Capacity (PWC130) At 6 Months

    Time frame: pre-intervention (at time point 0) and post-intervention (at 24 weeks)

    Measurement of heart rate (bpm) on the Corvial ergometer while increasing power manually by 25 W every 2 minutes. The endpoint is the power in Watts at the stage where heart rate of 130bpm is reached.

  12. Change From Baseline In Isometric Leg Extensor Strength For Each Leg At 6 Months

    Time frame: pre-intervention (at time point 0) and post-intervention (at 24 weeks)

    Measurement of leg extensor strength using a force transducer connected to the back of a chair and an ankle loop, as well as force recording software. The maximum force (N) will be multiplied with the distance from knee joint to the middle of the loop (in metres) to calculate the torque in Newton-metres (Nm) for each leg.

Sponsors and collaborators

Lead sponsor

Technical University of Munich

Other

Collaborators

  • LMU Klinikum
  • Rutgers University
  • Stanford University
  • Universitaet Innsbruck

Registry information

Official study title

Effect Of Daily Taurine Supplementation For 6 Months On Biological Age and Metabolic Biomarkers As Well As Physical Fitness In 55-75-year-old Women And Men: A Randomized Controlled Intervention Study

Acronym: TauAge

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
Sep 26, 2024
Registry last updated
Nov 21, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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