Muscle Metabolic Function in Older Adults With Different Vitamin D Status Before and After Exercise

This is a small pilot aerobic training trial designed to examine differences between normal-high and low vitamin D levels and 7-days of aerobic training on local VO2 measured by non-invasive Hybrid Diffuse Optical Spectroscopy.

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Key information

Conditions

Vitamin D Deficiency Avitaminosis Deficiency Diseases Malnutrition Nutrition Disorders Nutritional and Metabolic Diseases

Age range

65 year–75 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Kentucky

Lexington, Kentucky, 40506, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

65-75 years of age

Exclusion criteria

Currently have or have a history of cardiovascular or pulmonary disease that would preclude the involvement in the performance of exercise.
Uncontrolled diabetes or hypertension.
History of neurological conditions related to spinal derangement, disk disease, peripheral neuropathies, tremor and rigidity
History of leg/hip trauma, inflammation, infection rhabdomyolysis, or leg surgery in the past 3 months
Have a diagnosis of osteoporosis (as determined by DXA)
Participated in a resistance or aerobic training program in the last 3 months
Engage in more than 1 hr/week of vigorous activity
Body mass index >29
On hormone replacement therapy

Treatment and study plan

7 continuous days of aerobic training

Other

For 7 consecutive days, subjects will perform up to 45 minutes of exercise consisting of treadmill walking at a progressive intensity of about 60-65% of their maximum heart rate. This heart rate range is estimated to be below 60% VO2 max.

Primary outcomes

Muscle VO2 consumption

Time frame: Up to 3 months

The objective is to examine the difference in gastrocnemius VO2 consumption in individuals that either have normal-high or low 25(OH)D and are undergoing 7-days of a treadmill training program.

Sponsors and collaborators

Lead sponsor

David Travis Thomas

Other

Registry information

Official study title

A Pilot Study Investigating Differences in Muscle Metabolic Function in Individuals Aged 65-75 Years With Different Vitamin D Status Before and After 7-days of Aerobic Training

Important dates

Study start: 2013
Primary completion: 2013
Study completion: 2015
First posted: Jun 30, 2015
Registry last updated: Mar 17, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed