Skip to main content
OpenTrials
Not Yet Recruiting

NCT Number: NCT06671028

Mixed Local for Sciatic Block

Choice of local anesthetics is the major determinant of the characteristics of a peripheral nerve block. Short acting local anesthetics while provides faster onset suffer from shorter duration. On the other hand, long acting local anesthetics while provides long duration suffered from long onset time. The ideal local anesthetics should provide faster nerve block onset while providing reasonable duration to provide sustained postoperative analgesia. Mixing short and long acting local anesthetics for nerve blocks may appear to be the solution however previous published studies have demonstrated similar onset time to long acting local anesthetics and with reduced duration. Recently, the London Health Sciences Centre established an ambulatory surgical centre. Fast onset peripheral nerve block is desirable. Previous studies have not looked at popliteal sciatic block and anecdotally we feel addition of short acting local anesthetics appear to speed up onset. We are therefore interested in conducting a randomize trial to determine whether mixing short and long acting local anesthetics can speed up onset of surgical quality block.

Not Yet Recruiting

Trial opening soon.

Get Notified

Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adult patients (≥18 years old)
  • Scheduled for elective below-knee surgeries such as ankle arthroscopy, lower limb fracture fixation, toe surgeries, etc
  • Capable of providing informed consent

Exclusion criteria

  • History of allergic reaction to local anesthetics
  • Pre-existing neurological disorders affecting lower limbs
  • Significant renal or hepatic impairment
  • Pregnancy or breastfeeding
  • Less than 60kg
  • Inability to provide informed consent

Treatment and study plan

Ropivacaine and Lidocaine

Drug

Popliteal sciatic block using Ropivacaine 100 mg and Lidocaine 100 mg in 20 mL

Ropivacaine 0,5%

Drug

Popliteal sciatic block using ropivacaine 0.5% 20 mL

Primary outcomes

  1. Time to complete sensory block

    Time frame: Tested every 2 min up to 60 min

    The primary outcome is onset time for achievement of complete sensory block of the sciatic nerve determined via pinch test.

Secondary outcomes

  1. Duration of analgesia

    Time frame: up to 48 hours after discharge

    Patient self reported time to onset of pain or analgesics

  2. Pain score at 6 hour post-block

    Time frame: 6 hours after nerve block

    Numeric rating scale of patient self-reported pain at 6 hour after block placement

  3. Patient satisfaction

    Time frame: at 48 hour

    5 point categorical

Study contacts

Contact information is provided by the study sponsor or research team.

Cheng Lin

CONTACT

[email protected]

5196858500

Sponsors and collaborators

Lead sponsor

London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

Other

Registry information

Official study title

Ropivacaine Versus Ropivacaine With Lidocaine Mixture in Poplitial-Sciatic Nerve Block for Below Knee Surgeries- A Randomized, Single Center Study

Important dates

Study start
2025
Primary completion
2027
Study completion
2027
First posted
Nov 4, 2024
Registry last updated
Nov 4, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.