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NCT Number: NCT07246720

IPP-PSP Block vs. SPSIPB in Breast Surgery

This prospective, randomized clinical study aims to compare the analgesic efficacy of the interpectoral-pectoserratus plane block and the serratus posterior superior intercostal plane block for postoperative pain management in patients undergoing breast cancer surgery. Both techniques are ultrasound-guided regional anesthesia methods targeting different interfascial planes of the thoracic wall. The study will evaluate postoperative pain scores, opioid consumption, Quality of recovery and potential complications. The findings are expected to contribute to optimizing regional anesthesia strategies for enhanced recovery and improved analgesia following breast cancer surgery.

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Key information

Conditions

Postoperative Acute Pain Agnosia Breast Cancer Breast Diseases Breast Neoplasms Neoplasms Neoplasms by Site Nervous System Diseases Neurobehavioral Manifestations Neurologic Manifestations Pain Pain, Postoperative Pathologic Processes Pathological Conditions, Signs and Symptoms Perceptual Disorders Postoperative Complications Regional Anesthesia Signs and Symptoms Skin Diseases Skin and Connective Tissue Diseases

Age range

18 year–65 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 18-65 years of age
  • ASA I-II-III risk groups
  • Patients with informed consent
  • Patients undergoing breast cancer surgery

Exclusion criteria

• Ages <18 and >65

  • ASA ≥ IV
  • History of allergy to local anesthetics
  • Known coagulation disorders
  • Infection near the insertion site
  • Chronic analgesic use
  • Patients with diabetes mellitus and those receiving neoadjuvant chemotherapy (due to potential impairment of pain sensation)
  • Body mass index >30
  • Dementia or confusion
  • Lack of cooperation

Treatment and study plan

Interpectoral-Pectoserratus Plane Block

Procedure

Ultrasound-guided injection between pectoralis major-minor and pectoralis minor-serratus anterior planes.

Serratus Posterior Superior Intercostal Plane Block

Procedure

Ultrasound-guided injection between the serratus posterior superior muscle and the intercostal muscles.

Primary outcomes

  1. Cumulative opioid consumption

    Time frame: in the first 24 hours after completion of the surgical procedure

    Cumulative opioid consumption in the first 24 postoperative hours after the completion of the surgical procedure

Secondary outcomes

  1. Postsurgical Quality of Recovery measured by the Quality of Recovery questionnaire

    Time frame: first day after surgery

    Postsurgical recovery by Quality of Recovery questionnaire (QoR-15) on first (D1) day after surgery.

    The minimum score on the Quality of Recovery questionnaire is 0 and the maximum score 150. Higher scores mean better quality of recovery.

  2. Number of episodes of postoperative pain

    Time frame: In the first 24 hours after completion of the surgical procedure

    Number of episodes of postoperative pain (NRS score ≥ 4) at rest and at deep inspiration in the first 24 postoperative hours after the completion of the surgical procedure

Study contacts

Contact information is provided by the study sponsor or research team.

çağdaş baytar, MD

CONTACT

[email protected]

+905542255960

Sponsors and collaborators

Lead sponsor

Zonguldak Bulent Ecevit University

Other

Registry information

Official study title

Interpectoral-pectoserratus Plane Block vs. Serratus Posterior Superior Intercostal Plane Block for Postoperative Analgesia in Patients Undergoing Breast Cancer Surgery

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Nov 24, 2025
Registry last updated
Nov 24, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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