microRNAs Role in Pre-eclampsia Diagnosis

Pre-eclampsia is one of the most threatening pregnancy complications. So far neither a secure, competent therapy for PE nor effective biomarkers for a premature discovery has been achieved.The aim of our study was to identify miRNAs 136, 494 and 495 genes expression in exosomes of peripheral blood compared to umbilical cord mesenchymal stem cells conditioned media released exososomes in patients with PE, as valuable markers for PE early prediction.

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Key information

Conditions

Preeclampsia Female Urogenital Diseases and Pregnancy Complications Hypertension, Pregnancy-Induced Pre-Eclampsia Pregnancy Complications Urogenital Diseases

Age range

23 year–35 year

Sex eligibility

Female

Study type

Observational

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

To have an uncomplicated pregnancy:

gestational age at venipuncture between 20 - 42 weeks
no medical, obstetrical, or surgical complications
absence of labor at the time of venipuncture
delivery of a normal term (≥ 37 weeks) neonate whose birth weight was between the 10th and 90th percentile for gestational age

Exclusion criteria

Patients with chronic hypertension, renal disease, and fetuses affected with congenital anomalies were excluded

Treatment and study plan

Primary outcomes

The expression of miRNAs 136, 494 and 495 in exosomes of peripheral blood and UCMSCs conditioned media

Time frame: 2-3 months

Sponsors and collaborators

Lead sponsor

Cairo University

Other

Registry information

Official study title

Role of Mesenchymal Stem Cells Exosomes Derived microRNAs; miR-136, miR-494 and miR-495 in Pre-eclampsia Diagnosis and Evaluation

Important dates

Study start: 2016
Primary completion: 2017
Study completion: 2017
First posted: Jun 19, 2018
Registry last updated: Jun 19, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed