Metabolic Dynamics During Physical Activity

The aim of this study is to systematically Analyse the metabolome in capillary blood of healthy men and women at rest and during defined standardized physical activity under normobaric normoxia or hypoxia with a specific focus on metabolites and metabolic pattern related to energy metabolism. The metabolome analyses in capillary blood could give us also or more detailed insight into erythrocyte metabolic physiology because it is known for a longer time that the primary metabolism of the erythrocyte reflects its Oxygen Saturation via the glycolytic metabolites / intermediates pattern.

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Key information

Conditions

Healthy Men and Women Behavior Hypoxia Motor Activity Pathological Conditions, Signs and Symptoms Signs and Symptoms Signs and Symptoms, Respiratory

Age range

18 year–55 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Charite University Medicine, ECRC

Berlin, 13125, Germany

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

healthy volunteers
written informed consent

Exclusion criteria

known cardio-vascular, lung, metabolic, endocrine, hematologic, kidney or neurologic diseases
pregnancy, lactating period
unability to understand study content and aims and to give written informed consent

Treatment and study plan

running on a treadmill under normoxia or hypoxia

Other

30 min running (60% VO2max) on a treadmill under hypoxia (O2: 14%)
30 min running (60% VO2max) on a treadmill under normoxia (O2: 20%)

Primary outcomes

Change in capillary lactate/pyruvate Ratio (dimension-free)

Time frame: t = 0 min (before exercise); t = 10, 20 and 30 min during exercise; t = 50 and 60 min during recovery

marker for the ratio between anaerobic / aerobic glycolysis

Sponsors and collaborators

Lead sponsor

Charite University, Berlin, Germany

Other

Registry information

Official study title

Metabolic Dynamics During Physical Activity Under Normobaric Normoxia or Moderate Hypoxia - a Pilot Study

Important dates

Study start: 2016
Primary completion: 2017
Study completion: 2017
First posted: Apr 2, 2018
Registry last updated: Apr 2, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed