Effects of an Organic Plant-rich Diet on Gut Microbiome and Vascular Function (ORGAMIC Pilot Study)

Inclusion criteria

• Healthy men and women aged 20-40 years old.
• Body mass index between 18.5 and 30 kg/m2.
• Non-smokers
• Not already participating in a clinical trial.
• No diagnosed heart attack, stroke, angina, thrombosis, liver or kidney diseases, diabetes, chronic gastrointestinal disorder or cancer.
• Not currently taking any medication
• No history of excess alcohol intake or substance abuse.
• Happy to follow dietary instructions before and during the study and to attend the research centre for breakfast and lunch for a total of 10 days.
• Ability to prepare basic meals from ingredients provided.
• No food intolerances, allergies, hypersensitivity or follow any dietary restriction (e.g. gluten intolerance, coeliac, lactose intolerance) that will prevent your ability to follow the test diets.
• Weight stable (no weight change by more than 3 kg in the last 2 months).
• No travel arrangements outside the United Kingdom (UK) within the period of data collection.
• Able to understand the information sheet and willing to comply with study protocol.
• Able to give informed written consent.

Exclusion criteria

• Women who are pregnant, intending to become pregnant, or breastfeeding.
• Participation in another clinical trial - Unable to comply with the study protocol.
• Weight change >3kg in preceding 2 months and body mass index <18.5 or >30 kg/m2
• Current smokers, or reported giving up smoking within the last 6 months History of substance abuse, previous or current high alcohol intake (>28 units/week for males and >21 units/week for females).
• Reported history of Cardiovascular disease, diabetes, cancer, kidney, liver or bowel disease, gastrointestinal disorder or use of drug likely to alter gastrointestinal function)
• Blood pressure ≥160/100 mmHg
• Travel arrangements outside UK within the period of data collection.