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Completed

NCT Number: NCT03516890

Management of Spontaneous Ruptured Hepatocellular Carcinoma

To investigate the best treatment for hepatocellular carcinoma rupture

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Key information

Conditions

Rupture, Spontaneous Adenocarcinoma Carcinoma Carcinoma, Hepatocellular Digestive System Diseases Digestive System Neoplasms Disease Attributes Emergencies Hepatocellular Carcinoma Liver Diseases Liver Neoplasms Neoplasms Neoplasms by Histologic Type Neoplasms by Site Neoplasms, Glandular and Epithelial Pathologic Processes Pathological Conditions, Anatomical Pathological Conditions, Signs and Symptoms Rupture Liver

Age range

15 year–76 year

Sex eligibility

All sexes

Study type

Observational

About this study

To investigate the best treatment for hepatocellular carcinoma rupture, transcatheter arterial embolization or partial hepatectomy. Furthermore, to discuss the choice of emergency or staged hepatectomy.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Being diagnosed as hepatocellular carcinoma with tumor rupture; with complete data and without loss of follow-up

Exclusion criteria

  • Without complete data; with loss of follow-up; not hepatocellular carcinoma based on pathological diagnosis

Treatment and study plan

Partial hepatectomy

Procedure

Partial hepatectomy was comprised of single or multiple liver resections aiming to excise all macroscopic tumors.

Primary outcomes

  1. Overall survival of all patients

    Time frame: 5 years

    Overall survival difference between the partial hepatectomy group and the non-surgical group

Secondary outcomes

  1. Postoperative peritoneal dissemination

    Time frame: 5 years

    Postoperative peritoneal dissemination diagnosed by imaging examination

  2. Recurrence-free survival of all patients

    Time frame: 5 years

    Recurrence-free survival difference between the partial hepatectomy group and the non-surgical group

  3. Overall survival of partial hepatectomy patients

    Time frame: 5 years

    Overall survival difference between the emergency partial hepatectomy group and the staged partial hepatectomy group

  4. Recurrence-free survival of partial hepatectomy patients

    Time frame: 5 years

    Recurrence-free survival difference between the emergency partial hepatectomy group and the staged partial hepatectomy group

  5. Overall survival of staged partial hepatectomy patients

    Time frame: 5 years

    Overall survival difference between the staged early partial hepatectomy group and the staged late partial hepatectomy group

  6. Recurrence-free of staged partial hepatectomy patients

    Time frame: 5 years

    Recurrence-free survival difference between the staged early partial hepatectomy group and the staged late partial hepatectomy group

Sponsors and collaborators

Lead sponsor

Huazhong University of Science and Technology

Other

Registry information

Official study title

Management of Spontaneous Ruptured Hepatocellular Carcinoma - Partial Hepatectomy and Prognosis: A Retrospective Study

Important dates

Study start
2005
Primary completion
2015
Study completion
2017
First posted
May 4, 2018
Registry last updated
May 4, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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