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Completed

NCT Number: NCT00000252

Lack of Acute Tolerance Development to Effects of Nitrous Oxide - 4

The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. To examine the lack of acute tolerance development to the subjective, cognitive, and psychomotor effects of nitrous oxide in healthy volunteers.

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Key information

Conditions

Opioid-related Disorders Agnosia Chemically-Induced Disorders Mental Disorders Narcotic-Related Disorders Nervous System Diseases Neurobehavioral Manifestations Neurologic Manifestations Pathological Conditions, Signs and Symptoms Perceptual Disorders Signs and Symptoms Substance-Related Disorders

Age range

21 year–29 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 2

Primary location

University of Chicago, Anesthesia & Critical Care

Chicago, Illinois, 60637, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Please contact site for information.

Treatment and study plan

0% N2O

Drug

10% N2O

Drug

20% N2O

Drug

30% N2O

Drug

40% N2O

Drug

Primary outcomes

  1. Psychomotor performance

    Time frame: During inhalation

    Subjects will undergo psychomotor testing during 120 min inhalation session of each intervention

  2. Cognitive performance

    Time frame: During inhalation

    Subjects will under cognitive testing during 120 minute inhalation session of each intervention

Sponsors and collaborators

Lead sponsor

University of Chicago

Other

Collaborators

  • National Institute on Drug Abuse (NIDA)

Registry information

Official study title

Lack of Acute Tolerance Development to Effects of Nitrous Oxide

Important dates

Study start
1994
Primary completion
1996
Study completion
1996
First posted
Sep 21, 1999
Registry last updated
May 28, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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