Differential Acute Tolerance Development to Effects of Nitrous Oxide - 7

The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. To examine differential acute tolerance development to effects of nitrous oxide in humans.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Opioid-related Disorders Agnosia Chemically-Induced Disorders Mental Disorders Narcotic-Related Disorders Nervous System Diseases Neurobehavioral Manifestations Neurologic Manifestations Pathological Conditions, Signs and Symptoms Perceptual Disorders Signs and Symptoms Substance-Related Disorders

Age range

21 year–37 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 2

Primary location

University of Chicago, Anesthesia & Critical Care

Chicago, Illinois, 60637, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Please contact site for information.

Treatment and study plan

Nitrous Oxide

Drug

Primary outcomes

Pain intensity, pain bothersomeness

Time frame: 25, 70, & 115 min of inhalation and 40 min post

Subjects will inhale varying conc of nitrous oxide for 120 min with cold immersion of forearm at 25, 70, and 115 min and 40 min after inhalation. Pain intensity and bothersomeness will be assessed at each immersion.

Sponsors and collaborators

Lead sponsor

University of Chicago

Other

Collaborators

National Institute on Drug Abuse (NIDA)

Registry information

Official study title

Differential Acute Tolerance Development to Effects of Nitrous Oxide

Important dates

Study start: 1995
Primary completion: 1996
Study completion: 1996
First posted: Sep 21, 1999
Registry last updated: May 28, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed