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Completed

NCT Number: NCT00000262

Effects of Combined Sevoflurane and Nitrous Oxide Inhalation - 14

The purpose of this study is to determine the effects of combined sevoflurane and nitrous oxide inhalation on mood, psychomotor performance, and the pain response in humans.

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Key information

Conditions

Opioid-related Disorders Agnosia Chemically-Induced Disorders Mental Disorders Narcotic-Related Disorders Nervous System Diseases Neurobehavioral Manifestations Neurologic Manifestations Pathological Conditions, Signs and Symptoms Perceptual Disorders Signs and Symptoms Substance-Related Disorders

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Chicago, Anesthesia & Critical Care

Chicago, Illinois, 60637, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Please contact site for information.

Treatment and study plan

30% Nitrous oxide

Drug

0.4% Sevoflurane

Drug

0.2% sevoflurane

Drug

Placebo

Other

Primary outcomes

  1. Pain intensity, pain bothersomeness

    Time frame: During inhalation

    Inhalation was for 68 min divided into 4 blocks with nitrous oxide added during either block 2 or block 4

  2. Mood

    Time frame: During inhalation

    Inhalation was for 68 min divided into 4 blocks with nitrous oxide added during either block 2 or block 4

  3. Psychomotor performance

    Time frame: During inhalation

    Inhalation was for 68 min divided into 4 blocks with nitrous oxide added during either block 2 or block 4

Sponsors and collaborators

Lead sponsor

University of Chicago

Other

Collaborators

  • National Institute on Drug Abuse (NIDA)

Registry information

Official study title

Effects of Combined Sevoflurane and Nitrous Oxide Inhalation

Important dates

Study start
1996
Primary completion
1999
Study completion
1999
First posted
Sep 21, 1999
Registry last updated
May 27, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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