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Completed

NCT Number: NCT07582757

Joint Attention Processing in Social Threat Scenarios

This study set up two experiments using the free viewing video paradigm. By setting up social threat scenarios induced by humans (Experiment 1) and non social threat scenarios induced by objects (Experiment 2), combined with eye tracking and fNIRS technology, we explored the eye movement patterns and related brain activation characteristics of IJA in children with ASD.

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Key information

Age range

3 year–10 year

Sex eligibility

All sexes

Study type

Observational

Primary location

School of Foreign Languages, University of Electronic Science and Technology of China

Chengdu, Sichuan, 611731, China

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

-

For ASD group:

  • 3 years ≤ age ≤ 10 years;
  • a diagnosis of autism spectrum disorder based on clinical symptoms, confirmed using the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) and other auxiliary diagnostic scales, including the Autism Diagnostic Interview-Revised (ADI-R) and the Childhood Autism Rating Scale (CARS);
  • further confirmation of ASD symptoms by experimenters with established research reliability using the Autism Diagnostic Observation Schedule, Second Edition (ADOS-2), with severity scores reported;
  • absence of comorbid physical diseases or other psychiatric disorders, including normal vision (or corrected-to-normal vision) and normal hearing;
  • no receipt of medication, transcranial magnetic stimulation (TMS), or transcranial direct current stimulation (tDCS) within the past three months.

For TD group:The inclusion criterion for the TD group was a score below the cutoff on the Social Responsiveness Scale (SRS).

Exclusion criteria

-

For ASD group:

  • age < 3 years or > 10 years;
  • absence of a diagnosis of autism spectrum disorder based on the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) and other auxiliary diagnostic scales, including the Autism Diagnostic Interview-Revised (ADI-R) and the Childhood Autism Rating Scale (CARS);
  • failure to meet diagnostic criteria after confirmation of ASD symptoms by experimenters with established research reliability using the Autism Diagnostic Observation Schedule, Second Edition (ADOS-2);
  • presence of comorbid physical diseases or other psychiatric disorders, or problems with vision (or corrected-to-normal vision) and hearing;
  • receipt of medication, transcranial magnetic stimulation (TMS), or transcranial direct current stimulation (tDCS) within the past three months.

For TD group:

children were excluded if their scores on the Social Responsiveness Scale (SRS) exceeded the cutoff.

Treatment and study plan

Primary outcomes

  1. Gaze transitions

    Time frame: The two time windows of 48-56 seconds and 70-80 seconds.

    the number of transitions between face stimuli and unexpected stimuli

  2. The proportion of fixation time

    Time frame: The two time windows of 48-56 seconds and 70-80 seconds.

    The proportion of fixation time on AOI is calculated as the fixation time on AOI divided by the total valid fixation time on the screen within each phase

  3. Activation concentration

    Time frame: The two time windows of 48-56 seconds and 70-80 seconds.

    the concentration of cortical activation during video viewing

Sponsors and collaborators

Lead sponsor

University of Electronic Science and Technology of China

Other

Registry information

Official study title

The Proactive and Joint Attention Processing Characteristics of Children With Autism Induced by Social Threat Scenarios

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
May 13, 2026
Registry last updated
May 13, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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