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NCT Number: NCT07130305

is There an Effect of Adding Body Vibration to Intake of Vitamin D on Some Outcomes of Familial Mediterranean Fever

Familial mediterranean fever (FMF) is common in mediterranean region. this disorder is connected with deterioration in functional performance, fitness of cardiorespiration, muscle strength, and bone mass

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Key information

Conditions

Familial Mediterranean Fever Congenital, Hereditary, and Neonatal Diseases and Abnormalities Genetic Diseases, Inborn Hereditary Autoinflammatory Diseases

Age range

13 year–17 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

About this study

Familial mediterranean fever (FMF adolescent girls ) will be collected to be cateogarized to vibration group (vibration group) or control grouping. every group OF FMF will contain 20 FMF adolescent girls. both groups will receive vitamin D and their traditional colchicine doses daily for six months. vibration group will receive three sessions of 20-min whole body vibration in the week for 6 months

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

FMF adolecent girls ages 13 -17 years forty patients

Exclusion criteria

cardiac problems renal problems liver problems diabetes brain problems

Treatment and study plan

whole body vibration plus usual care

Other

Familial mediterranean fever (20 FMF adolescent girls ) will be in this vibration group who will receive vitamin D and their traditional colchicine doses daily for six months. vibration group will also receive three sessions of 20-min whole body vibration in the week for 6 months

Usual Care

Other

Familial mediterranean fever (20 FMF adolescent girls ) will be in this control group who will receive vitamin D and their traditional colchicine doses daily for six months.

Primary outcomes

  1. bone mineral density

    Time frame: it will be measured after 6 months

    it is a measure for bone density at 2-4 lumbar vertebrae

Secondary outcomes

  1. z score

    Time frame: it will be measured after 6 months

    it is a score for measure for bone mass at 2-4 lumbar vertebrae

  2. vitamin D

    Time frame: it will be measured after 6 months

    it will measured in plasma as serum 25-hydroxyvitamin D

  3. osteoprotegerin

    Time frame: it will be measured after 6 months

    it will measured in plasma

  4. quadriceps torque

    Time frame: it will be measured after 6 months

    it will measured in dominant side

  5. Standing long jump test

    Time frame: it will be measured after 6 months

    it is an indicator for functional performance

  6. Thirty second sit to stand test

    Time frame: it will be measured after 6 months

    it is an indicator for functional performance

  7. Ruffier index

    Time frame: it will be measured after 6 months

    it is an indicator for cardiorespirtory fittness

Study contacts

Contact information is provided by the study sponsor or research team.

Ali Ismail

CONTACT

[email protected]

Ali MA Ismail, lecturer

CONTACT

[email protected]

01005154209

Sponsors and collaborators

Lead sponsor

Cairo University

Other

Registry information

Official study title

is There an Effect of Addition of Body Vibration to Intake of Vitamin D on Some Outcomes of Familial Mediterranean Fever

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Aug 19, 2025
Registry last updated
Aug 19, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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