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Completed

NCT Number: NCT00512226

Iron Overload Assesment in Sickle Cell Anemia and Sickle Cell Thalassemia

Iron overload is well study in Thalassemia patients and it's not only related to blood transfusions, since intestinal iron absorption is also increased in those patients. Sickle cell patients didn't develope significant clinical symptoms and signs of iron overload in spite frequent transfusions. The purpouse of this study is to assess the iron overload in Sickle cell anemia and Sickle cell Thalassemia patients using clinical parameters and cardiac T2*MRI in order to determine the cardiac and liver iron.

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Key information

Conditions

Sickle Cell Anemia Anemia Anemia, Hemolytic Anemia, Hemolytic, Congenital Anemia, Sickle Cell Congenital, Hereditary, and Neonatal Diseases and Abnormalities Genetic Diseases, Inborn Hematologic Diseases Hemic and Lymphatic Diseases Hemoglobinopathies Iron Metabolism Disorders Iron Overload MRI Metabolic Diseases Nutritional and Metabolic Diseases Sickle Cell Thalassemia

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Pediatric Hematology Unit and Pediatric Dpt B - HaEmek Medical Center

Afula, 18101, Israel

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • All the patients with Sickle cell anemia and Sickle cell Thalasemia that are currently in follow up at the Pediatric Hematology Unit

Exclusion criteria

  • Age below 18 years.

Treatment and study plan

Cardiac and Liver T2* MRI

Other

Laboratory examinations that are routinely used in follow up of those patients and T2* MRI analysis.

Primary outcomes

  1. Assessment of Iron overload.

    Time frame: December 2008

Secondary outcomes

  1. Institute the criteria for iron chelator treatment

    Time frame: December 2008

Sponsors and collaborators

Lead sponsor

HaEmek Medical Center, Israel

Other

Collaborators

  • Wolfson Medical Center

Registry information

Official study title

Clinical and Laboratory Assessment of Iron Overload in Sickle Cell Anemia and Sickle Cell Thalassemia Using T2* Cardiac MRI.

Important dates

Study start
2007
Primary completion
2010
Study completion
2010
First posted
Aug 7, 2007
Registry last updated
Aug 26, 2011

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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