NCT Number: NCT03547128
A cohort of newborns was recruited for the Iowa Fluoride Study from 1992-95 to assess the complex relationships among fluoride intakes, fluoride exposures, dental fluorosis, and dental caries. Detailed questionnaires were sent every 1.5-6 months concerning water sources, fluoride exposures, dietary intakes, etc. Standardized dental exams were conducted at ~ages 5, 9, 13, 17, and 23. At about age 5, participants were invited to join the offshoot Iowa Bone Development Study. Bone densitometry assessments were conducted at ages 5, 8, 11, 13, 15, 17, 19, and 23. These included Dual-energy X-ray Absorptiometry (DXA) of hip, lumbar spine, and whole body from age 5; peripheral Quantitative Computed Tomography (pQCT) of the radius and tibia from age 11; and Multi-Detector Computed Tomography (MDCT) of the tibia from age 19. Physical activity and other factors also were assessed longitudinally.
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Notify Me1 month–30 year
All sexes
Observational
A cohort of newborns was recruited for the Iowa Fluoride Study from 1992-95 to assess the complex relationships among fluoride intakes, fluoride exposures, dental fluorosis, and dental caries. Detailed questionnaires were sent every 1.5-6 months concerning water sources, fluoride exposures, dietary intakes, etc. Standardized dental exams were conducted at ~ages 5, 9, 13, 17, and 23. At about age 5, participants were invited to join the offshoot Iowa Bone Development Study. Bone densitometry assessments were conducted at ages 5, 8, 11, 13, 15, 17, 19, and 23. These included Dual-energy X-ray Absorptiometry (DXA) of hip, lumbar spine, and whole body from age 5; peripheral Quantitative Computed Tomography (pQCT) of the radius and tibia from age 11; and Multi-Detector Computed Tomography (MDCT) of the tibia from age 19. Physical activity and other factors also were assessed longitudinally.
Healthy volunteers accepted: Yes
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
Exclusion criteria
Time frame: age 5
dental fluorosis exam results
Time frame: age 9
dental fluorosis exam results
Time frame: age 13
dental fluorosis exam results
Time frame: age 17
dental fluorosis exam results
Time frame: age 23
dental fluorosis exam results
Time frame: age 5
dental caries exam results
Time frame: age 5
dental caries exam results
Time frame: age 9
dental caries exam results
Time frame: age 17
dental caries exam results
Time frame: age 23
dental caries exam results
Time frame: age 5
DXA scans
Time frame: age 8
DXA scans
Time frame: age 11
DXA and pQCT scans
Time frame: age 13
DXA and pQCT scans
Time frame: age 15
DXA and pQCT scans
Time frame: age 17
DXA and pQCT scans
Time frame: age 19
DXA, pQCT, and MDCT scans
Time frame: age 23
DXA, pQCT, and MDCT scans
Steven M Levy
Other
Acronym: (IFS/IBDS)
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View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.
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