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NCT Number: NCT07335029

Investigation of Hemodynamics and Radiomics Based on High Resolution Magnetic Resonance Imaging for Predicting the Outcomes of Intracranial Dissecting Aneurysm

This study aims to conduct a comprehensive analysis by integrating clinical factors, aneurysm morphological characteristics, and factors reflecting pathophysiological processes (such as hemodynamic and radiomics features), in order to explore the hemodynamic mechanisms associated with the progression of intracranial dissecting aneurysms. Furthermore, artificial intelligence algorithms will be employed to develop and validate an intelligent risk prediction model for the progression and outcomes of intracranial dissecting aneurysms.

Active, Not Recruiting

This study is active but is not currently recruiting participants.

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Key information

Conditions

Cerebrovascular Disease Aneurysm Brain Diseases Cardiovascular Diseases Central Nervous System Diseases Cerebrovascular Disorders Intracranial Aneurysm Intracranial Arterial Diseases Intracranial Arterial Dissection Nervous System Diseases Vascular Diseases

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Beijing Tiantan Hospital, Capital Medical University

Beijing, Beijing Municipality, 107000, China

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Intracranial dissecting aneurysm clearly diagnosed by DSA and high-resolution MRI imaging (according to the imaging diagnostic criteria proposed in the Chinese Expert Consensus on Imaging Diagnosis of Intracranial Arterial Dissection)
  • patients managed with conservative treatment and follow-up
  • patients who agree and sign a written informed consent form

Exclusion criteria

  • Arteritis, fibromuscular dysplasia, iatrogenic or traumatic pseudoaneurysms
  • Contraindications to MRI examination (such as claustrophobia or metallic implants), or contraindications to cerebral angiography (such as iodine contrast allergy)
  • Dissecting aneurysms extending from the extracranial segment to the intracranial segment, or cases with concomitant intracranial atherosclerotic plaques in the affected vessels
  • Patients who refuse MRI examination
  • Patients with severe comorbid diseases and an expected survival time of less than 2 years due to these conditions
  • Patients without follow-up HR-MRI imaging for any reason

Treatment and study plan

Primary outcomes

  1. Progression of intracranial dissecting aneurysms

    Time frame: From enrollment to 12 months of follow-up

Sponsors and collaborators

Lead sponsor

Beijing Neurosurgical Institute

Other

Registry information

Important dates

Study start
2023
Primary completion
2027
Study completion
2027
First posted
Jan 12, 2026
Registry last updated
Jan 12, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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