Florida Cerebrovascular Disease Biorepository and Genomics Center

The purpose of this study is to create a state-wide biorepository and resource center for cerebrovascular diseases in Florida, which will include collecting medical history information and blood from subjects affected by cerebrovascular disease. The information and blood samples collected may be used in future research for the study of cerebrovascular disease and to learn about, prevent or treat other health problems.

Active, Not Recruiting

This study is active but is not currently recruiting participants.

Key information

Conditions

Cerebrovascular Disease Aneurysmal Subarachnoid Hemorrhage Anoxic Brain Injury Arterial Occlusive Diseases Arteriosclerosis Arteriovenous Fistula Arteriovenous Malformations Asymptomatic Carotid Artery Stenosis Brain Diseases Brain Infarction Brain Ischemia CADASIL Cardiovascular Abnormalities Cardiovascular Diseases Carotid Artery Diseases Carotid Artery Stenosis Symptomatic Central Nervous System Diseases Cerebral Arterial Diseases Cerebral Hemorrhage Cerebral Infarction Cerebral Small Vessel Diseases Cerebral Venous Thrombosis Cerebrovascular Disorders Congenital Abnormalities Congenital, Hereditary, and Neonatal Diseases and Abnormalities Dementia Dementia, Vascular Embolism and Thrombosis Fibromuscular Dysplasia Fistula Genetic Diseases, Inborn Hemorrhage Hypoxia Hypoxia, Brain Hypoxia-Ischemia, Brain Infarction Intracerebral Hemorrhage Intracranial Arterial Diseases Intracranial Arteriosclerosis Intracranial Embolism and Thrombosis Intracranial Hemorrhages Intracranial Thrombosis Ischemia Ischemic Attack, Transient Ischemic Stroke Leukoaraiosis Leukoencephalopathies Mental Disorders Moyamoya Disease Necrosis Nervous System Diseases Neurocognitive Disorders Non-Aneurysmal Perimesencephalic Subarachnoid Haemorrhage Pathologic Processes Pathological Conditions, Anatomical Pathological Conditions, Signs and Symptoms Reversible Cerebral Vasoconstriction Syndrome Signs and Symptoms Signs and Symptoms, Respiratory Stroke Subarachnoid Hemorrhage Thromboembolism Transient Ischemic Attack Unruptured Intracranial Aneurysm Vascular Dementia Vascular Diseases Vascular Fistula Vascular Malformations

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Mayo Clinic Florida

Jacksonville, Florida, 32224, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Affected subjects with diverse cerebrovascular conditions, including, but not limited to, ischemic stroke, transient ischemic attack (TIA), intracerebral hemorrhage (ICH), aneurysmal subarachnoid hemorrhage (aSAH), vascular dementia (VAD), anoxic brain injury, unruptured intracranial aneurysm (UIA), cavernous malformation, arteriovenous malformations (AVM), carotid and vertebral arterial dissections, symptomatic and asymptomatic cervical carotid artery atherosclerotic stenosis, non-aneurysmal perimesencephalic subarachnoid hemorrhage (naSAH), cerebral venous thrombosis (CVT), moyamoya disease, fibrosmuscular dysplasia (FMD), non-traumatic, angiography-negative subarachnoid hemorrhage, leukoaraiosis, arteriovenous fistula, reversible cerebral vasoconstriction syndrome (RCVS), and CADASIL.

Exclusion criteria

All patients with the following known or suspected virulent microorganisms causing an active or latent infection will be excluded from the study:

Human immunodeficiency virus (HIV);
Any viral hepatitis;
West Nile virus (WNV);
Influenza virus;
Tuberculosis (TB);
Any bacteremia;
Any fungemia;
Any prionopathy.

Treatment and study plan

Primary outcomes

Stroke or TIA at 12 months

Time frame: 1 year

Number of participants to experience new diagnosis of TIA or stroke.

Secondary outcomes

Modified Rankin Scale

Time frame: 1 year

Measure of overall functional status

Sponsors and collaborators

Lead sponsor

Mayo Clinic

Other

Registry information

Official study title

Creating a Florida Cerebrovascular Disease Biorepository and Genomics Center

Important dates

Study start: 2022
Primary completion: 2026
Study completion: 2026
First posted: Aug 8, 2022
Registry last updated: May 13, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Recruiting