Creation of a Biological Collection for Medical Research Purposes for Patients at the Reference Center for Rare Diseases of the Blood Vessels of the Brain and Eye at Lariboisière Hospital

The aim of establishing a biological collection associated with the existing rare cerebral vascular disease cohort is to identify new prognostic or disease progression biomarkers that could improve patient care or identify new therapeutic targets.

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This study is active but is not currently recruiting participants.

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Key information

Conditions

Cerebrovascular Disease Brain Diseases Cardiovascular Diseases Central Nervous System Diseases Cerebrovascular Disorders Nervous System Diseases Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Lariboisière hospital

Paris, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Confirmed diagnosis of a rare cerebral vascular disease of the brain, including:

Familial intracranial aneurysms, cerebral amyloid angiopathy, CADASIL, familial cerebral cavernoma, familial cervical or intracranial artery dissection, vascular leukoencephalopathy (hereditary), familial hemiplegic migraine, cerebral arteriovenous malformation, moya-moya, cerebral venous thrombosis, hereditary retinal tortuosity, cerebro-retinal vasculopathies, other known rare diseases, or other rare diseases that are undetermined or not yet described.

Participation in the MVCR cohort
Adults >18 years old
Affiliation with French social security or beneficiary - Signature of informed consent

Exclusion criteria

Incompatibility with long-term follow-up at CERVCO
Patient under guardianship/conservatorship
Pregnant or breastfeeding women
Patient under AME

Treatment and study plan

additional samples for research purposes

Other

Blood and urine sampling

Primary outcomes

Time required for sample storage (freezing) to ensure the stability of most measurable elements in a biological sample

Time frame: Up to 2 years after inclusion

for each sample

Sponsors and collaborators

Lead sponsor

Assistance Publique - Hôpitaux de Paris

Other

Registry information

Official study title

Constitution d'Une Collection Biologique à Des Fins de Recherche médicale Pour Les Patients du Centre de référence Des Maladies Rares Des Vaisseaux du Cerveau et de l'Oeil à l'hôpital Lariboisière

Acronym: B-MRVC

Important dates

Study start: 2021
Primary completion: 2027
Study completion: 2027
First posted: Dec 4, 2025
Registry last updated: Dec 4, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

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