Intestinal Microbiota and Postoperative Ileus After Colorectal Surgery

Postoperative ileus (POI) after colorectal surgery is frequent and is a burden for national health authority because it increases the morbidity and the length of hospital stay.

Some of the stage of the mechanism of POI are known and are now targeted to reduce its occurence but despite these measures, POI still happens in 10-30% of surgeries.

The role of the intestinal microbiota in POI is unknown while it could be a new target to reduce its duration or its occurence.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Postoperative Ileus Surgery-Complications

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Angers University Hospital, visceral and endocrine surgery department

Angers, 49000, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

laparoscopic colorectal resection with anastomosis and without diverting stoma

Exclusion criteria

risk of modification of the microbiota (terminal enterostomy, chronic inflammatory bowel disease, oesophageal or gastric surgery, vagal nerves lesion, beta lactamin allergy, bowel cleansing)
postoperative complication

Treatment and study plan

Feces collection

Other

Feces will be collected, at home, by the patient., by using a collection kit. The stools are collected in the 2 last days before surgery.

After surgery, the first stool is collected, during the hospitalization, by using the same kit. Stools are conserved in the same condition, before being frozen in our local biologic ressources center.

Primary outcomes

Composition of the feces microbiota before surgery

Time frame: within the 2 last days before surgery

The composition of the microbiota will be assessed by the analysis of the region V3 V4 of the 16S rRNA, amplificateur by high flow sequencing
Composition of the feces microbiota after surgery

Time frame: up to the first postoperative stools, an average of 3 postoperative days

The composition of the microbiota will be assessed by the analysis of the region

Sponsors and collaborators

Lead sponsor

University Hospital, Angers

Other Gov

Collaborators

Institut National de la Santé Et de la Recherche Médicale, France

Registry information

Official study title

Evaluation of the Role of the Intestinal Microbiota in the Mechanism of Postoperative Ileum After Colorectal Surgery : a Preliminary Study

Acronym: MICRO-IPO

Important dates

Study start: 2022
Primary completion: 2025
Study completion: 2025
First posted: Aug 23, 2022
Registry last updated: Jun 15, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed