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Completed

NCT Number: NCT05296967

Study of the Efficience of Chewing-gum to Reduce the Duration of Postoperative Ileus

Postoperative ileus (POI) is a serious complication after surgery. While it complicates all type of surgery, it is more frequent after abdominal surgery (especially bowel or colorectal surgery).

Many studies aim to reduce the occurence of POI without efficiency. The aim of this study is to assess the efficiency of the vagal stimulation, by the mean of chewing, to reduce the duration of POI.

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Key information

Conditions

Postoperative Ileus

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University Hospital aof Angers, Angers, France

Loading trial locations.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • patients undergoing colorectal surgery or small bowel surgery
  • elective or in emergency
  • open surgery or laparoscopy
  • diagnosis of POI
  • indication of fasting or nasogastric tube placement

Exclusion criteria

  • contra-indication of chewing
  • pregnancy

Treatment and study plan

chewing

Behavioral

patients are asked to chew chewing gum X 3/ day

Primary outcomes

  1. To assess the efficiency of chewing gum in reducing the duration of POI. POI is defined by the criteria of Vather from the postoperative day 1 up to day 30

    Time frame: collected each day until the end of the POI, assessed up to day 21

    The duration of POI is the time between the first day of meeting the criteria of Vather to the day of recovery of tolerance of solid food and of exoneration of stool and/or flatus (GI-3 recovery).

    Patients will be asked to report in their diary the day of tolerance of solid food and of exoneration of stool and/or flatus (GI-3 recovery) after the diagnosis of POI

Sponsors and collaborators

Lead sponsor

University Hospital, Angers

Other Gov

Collaborators

  • Centre Hospitalier de Cholet

Registry information

Official study title

Efficiency of Chewing-gum to Reduce the Duration Postoperative Ileus: a Randomized Controlled Study

Acronym: CHEWIP

Important dates

Study start
2022
Primary completion
2025
Study completion
2025
First posted
Mar 25, 2022
Registry last updated
Jul 20, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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