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NCT Number: NCT07230951

Interaction Between White Potato Consumption and Meal Timing on Glycemic Response and Appetite in Adults

The purpose of this study is to evaluate the interaction between white potato consumption and meal timing on glycemic response, subjective appetite, and energy intake in adults. The investigators hypothesize that white potatoes will modulate glycemic response, enhance satiety, and mitigate subsequent meal consumption and overall food intake when compared with meals containing low glycemic carbohydrates. Furthermore, they anticipate that the timing of white potato consumption will yield differential effects, with breakfast consumption exerting a more pronounced impact on satiety and subsequent food intake reduction compared to dinner consumption.

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Key information

Conditions

Healthy Adult Appetite Glycemic Response Mealtiming

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Centre for Urban Innovation (CUI-109), School of Nutrition, Toronto Metropolitan University

Toronto, Ontario, M5B2K3, Canada

Location status: Recruiting

Location contact

Nick Bellissimo

CONTACT

[email protected]

4169795000 ext. 553103

About this study

A randomized within-subject repeated measures experiment will be used to study the interaction between white potato consumption and meal timing on glycemic response, subjective appetite, and energy intake in adults. In Experiment 1, participants will consume, in a random order on separate mornings, one of six test meals consisting of an egg omelette and a test side of: (1) Oven-baked home fries, (2) Oven-baked white russet potatoes, (3) Deep-fried, quick serve fries, (4) Oven-baked fries, (5) Oven-baked cauliflower tots, or (6) no side. Acute glycemic response and subjective appetite will be measured at baseline and over 120-mins post treatment consumption. At 120-min, food intake will be evaluated via an ad libitum lunch. Rest of day food intake and glycemic response will be collected until the participant goes to bed. Blood glucose measurements will be collected using the Dexcom G7 continuous glucose monitoring system.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 18 - 65 years
  • within the healthy body weight range [body mass index (BMI) between 18.5 - 24.9 kg/m2].

Exclusion criteria

  • have a previous diagnosis of diabetes and gastrointestinal, liver or kidney disease;
  • have had a major medical or surgical event within the past 6 months;
  • have had any significant weight fluctuation in the past 6-months;
  • are taking medication that may influence dependent measures;
  • are or have been on a diet within the past 6 months;
  • skip breakfast or are unable to consume test treatment food.

Treatment and study plan

Oven-baked Home Fries

Other

Oven-baked Home Fries (241 g; McCain Ltd.). Test treatments matched for calories (284 kcal)

Oven-baked White Russet Potato

Other

Oven-baked White Russet Potato (299 g). Test treatments matched for calories (284 kcal)

Oven-baked Fries

Other

Oven-baked Fries (201 g; McCain Ltd.). Test treatments matched for calories (284 kcal)

Deep Fried, Quick Serve Fries

Other

Deep Fried, Quick Serve Fries (108 g; McCain Ltd.). Test treatments matched for calories (284 kcal)

Oven-baked Cauliflower Veggie Tots

Other

Oven-baked Cauliflower Veggie Tots (186 g; Green Giant). Test treatments matched for calories (284 kcal)

No Side

Other

No side control (no caloric contribution).

Primary outcomes

  1. Glycemic Response (Acute Phase)

    Time frame: Change from baseline (measured at baseline (0-minute), 15-minute, 30-minute, 60-minute, 90-minute, and 120-minute post-treatment consumption).

    Blood glucose (mmol/L). Blood glucose concentrations will be measured using a Dexcom G7 CGM system.

  2. Rest-of-day Blood Glucose

    Time frame: Continuous measurements for 24 hours post-treatment consumption.

    Blood glucose (mmol/L). Rest-of-day blood glucose concentrations will be determined using a Dexcom G7 CGM system.

  3. Ad Libitum Food Intake

    Time frame: At 120 minutes post-treatment consumption

    Lunch pizza meal. Food intake will be determined by weighing the meal before and after serving. The net weight of the test meal will be converted to calories.

Secondary outcomes

  1. Subjective Appetite

    Time frame: Change from baseline (measured at baseline (0-minute), 15-minute, 30-minute, 60-minute, 90-minute, and 120-minute post-treatment consumption).

    A visual analogue scale (VAS) with four questions will be administered to assess desire to eat, fullness, hunger, and prospective food consumption. Individual questions will be used to form a composite score. Each VAS will be administered via a digital software application (Express VAS, Toronto, Ontario, Canada) on a Dell tablet where participants will place an 'X" on the VAS line (100 unit scale).

  2. Rest-of-day Food Intake

    Time frame: For the rest of the day following test session completion (1 day)

    Participants will be sent home with a rest-of-the-day food intake recall sheet to record their snacks, meals, and beverages. Rest of day food log.

  3. Subjective Emotions

    Time frame: Change from baseline (measured at baseline (0-minute), 15-minute, 30-minute, 60-minute, 90-minute, and 120-minute post-treatment consumption).

    A visual analogue scale (VAS) with thirteen questions will be administered to assess subjective emotions and mood (aggression, anger, excitement, disappointment, happiness, upset, frustration, alertness, sadness, tension, exhaustion, calmness, and sleepiness). Individual questions will be used to form a composite emotion score. Each VAS will be administered via a digital software application (Express VAS, Toronto, Ontario, Canada) on a Dell tablet where participants will place an 'X" on the VAS line (100 unit scale).

Sponsors and collaborators

Lead sponsor

Toronto Metropolitan University

Other

Collaborators

  • Alliance for Potato Research and Education

Registry information

Official study title

Interaction Between White Potato Consumption and Meal Timing on Glycemic Response, Subjective Appetite, and Energy Intake in Adults.

Important dates

Study start
2025
Primary completion
2027
Study completion
2027
First posted
Nov 17, 2025
Registry last updated
Nov 17, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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