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OpenTrials
Completed

NCT Number: NCT01271829

Incorporating Avocados in Meals

The purpose of this study is to examine the effect of incorporating avocados in meals on post-ingestion glycemic index, insulin response, sensations of satiety and on appetite-related gastrointestinal peptide and hormone release. Also the effect of consuming avocado containing meals on the caloric intake of participants in subsequent eating episodes will be explored.

Each subject will participate in one intervention for one day, wait one or two weeks, come for another intervention, wait one or two weeks and come for a final intervention- three in total. Participants will be randomly assigned to one of six treatment sequences. Postprandial response to the control and two avocado-containing test meals will be assessed and compared using a 3 x 3 single blind cross-over design. The Subjects will be between 25 and 60 years old, female or male, with a BMI of 23 to 32, stable weight, no sports involvement, non-smoking and not dependent on caffeine. Thirty subjects will be recruited.

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Key information

Age range

23 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Loma Linda University, Department of Nutrition

Loma Linda, California, 92350, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 23-60 years old
  • BMI 23-32
  • Stable weight for 6 months
  • Live or work near Loma Linda University

Exclusion criteria

  • Smoker
  • Heavy involvement in sports
  • Dependent on caffeine

Treatment and study plan

Avocado supplement

Dietary Supplement

Calories from avocados replace calories of the control lunch

Avocado included

Dietary Supplement

Calories from avocados will be added to calories from the control lunch

Primary outcomes

  1. Satiety

    Time frame: 12 hours

    The effect that consumption of avocados has on feelings of fullness and the quantity of food consumed in a subsequent eating episode

Secondary outcomes

  1. post-ingestion glycemic index

    Time frame: 3 hours

    Blood will be drawn at 30 minutes, 60 minutes, 120 minutes and 180 minutes after consumption of a meal with or without avocados. The glycemic index will be analyzed.

  2. insulin response

    Time frame: 3 hours

    Blood will be drawn at 30 minutes, 60 minutes, 120 minutes and 180 minutes after consumption of a meal with or without avocados. Insulin response will be analyzed.

  3. appetite-related gastrointestinal peptide and hormone release

    Time frame: 3 hours

    Blood will be drawn at 30 minutes, 60 minutes, 120 minutes and 180 minutes after consumption of a meal with or without avocados. Gastrointestinal peptide and hormones will be analyzed.

Sponsors and collaborators

Lead sponsor

Loma Linda University

Other

Collaborators

  • Hass Avocado Board

Registry information

Official study title

Incorporating Avocados in Meals: Effect on Glycemic Index, Insulin Response, Satiety and Satiety-related Gastrointestinal Peptides in Humans

Important dates

Study start
2011
Primary completion
2012
Study completion
2012
First posted
Jan 7, 2011
Registry last updated
Mar 18, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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