Leatherhead Food Research
Leatherhead, Surrey, KT22 7RY, United Kingdom
NCT Number: NCT01999504
The effects of two palaeolithic-type meals will be assessed with respect to a panel of gut hormones, satiety, blood glucose and insulin levels as compared to a meal constructed along the lines of the world Health Organisation dietary recommendations
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Notify Me18 year–60 year
Male
Interventional
Not applicable
Leatherhead, Surrey, KT22 7RY, United Kingdom
In the current study the effects of two palaeolithic-type meals will be assessed with respect to a panel of gut hormones (including incretins), satiety, blood glucose and insulin levels.
Healthy volunteers accepted: Yes
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
Exclusion criteria
meal
Meal
Meal
Time frame: 0-3 hours
Area under the Concentration versus time curve for Glucagon-like peptide-1 in blood plasma
Time frame: 0-3 hours
Area under the Concentration versus time curve of Glucose-dependent Insulinotropic Peptide in blood plasma
Time frame: 0-4 hours
Area under the curve for fullness scores (as rated by the subjects on a Visual Analog Scale) versus time
Time frame: 0-3 hours
Area under the Concentration versus time curve of Glucose in blood
Time frame: 0-3 hours
Area under the Concentration versus time curve of insulin in blood plasma
Time frame: 0-3 hours
Area under the Concentration versus time curve of Glucagon in blood plasma
Time frame: 0-3 hours
Area under the Concentration versus time curve of Peptide YY in blood plasma
Time frame: 0-4 hours
Area under the curve for hunger scores (as rated by the subjects on a Visual Analog Scale) versus time
Time frame: 0-4 hours
Area under the curve for desire to eat scores (as rated by the subjects on a Visual Analog Scale) versus time
Time frame: 30 minutes
Ratio between insulin and glucose in blood as measured at 30 minutes after start of test product intake
Time frame: 4 hours
Weight of an ad libitum pasta with tomato sauce meal consumed at 4 hours after test product intake
Time frame: up to 4 hours
Time to return to baseline for the scores on a Visual Analogue Scales for fullness, hunger and desire to eat
Time frame: 0-3 hours
Area under the Concentration versus time curve for total amylin, ghrelin, pancreatic polypeptide, C-peptide, leptin, interleukin-6, monocyte chemotactic protein-1 and tumour necrosis factor-alpha in blood plasma
Unilever R&D
Industry
Gut Hormone Response After Two Paleolithic-type Meals Compared to a Modern-type Meal Composed According to WHO Guidelines
Acronym: FooA2
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