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Completed

NCT Number: NCT03207607

Mid-morning Gel Snacks on Subjective Appetite, Glycemic and Insulin Responses, and Food Intake

The purpose of this study was to determine the effect of mid-morning gel snacks on subjective appetite, glucose and insulin responses, and food intake in healthy weight young adults.

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Key information

Age range

18 year–30 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

School of Nutrition, Ryerson University

Toronto, Ontario, M5B 2K3, Canada

About this study

23 (14 male, 9 female) healthy, non-smoking human subjects aged 18-30 years with a body mass index (BMI) between 20 and 24.9 were recruited in the experiment. Five gel snacks including a control snack and four modified snacks containing whey protein, oats, coconut oil or maltodextrin were tested. On six separate mornings, at least 3 days apart and after a 12 hours overnight fast, each participant consumed a standardized breakfast of cereal, milk, and orange juice at home, then arrived in the lab 2 hours after breakfast to receive one of the five test snack treatments or skip snack. Subjective appetite by a 100 mm visual analogue scale (VAS) was measured at baseline (0 min) and after each treatment up to 2 h (15, 30, 60, 90, and 120 min). Blood glucose and insulin concentrations were measured via finger-prick at the same time VAS measurements were taken. Food intake was measured via ad libitum pizza lunch.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • be between 18 and 30 years of age
  • be healthy, non-smoking and not be taking any medications, including birth control
  • body mass index (BMI) between 20 and 24.9

Exclusion criteria

  • fasting plasma glucose >5.5 mmol/L
  • health problems including previously diagnosed diabetes, known or uncertain pregnancy status at screening, gastrointestinal disease, liver or kidney disease
  • major medical or surgical event within the past 6 months
  • current or recent dieting
  • breakfast skipping
  • receiving any medications
  • menstrual irregularities
  • food sensitivities, allergies, intolerances, or dietary restrictions to foods including: cereal, orange juice, dairy, oat, coconut oil, honey, apple, pineapple, strawberry, and pear
  • behavioural or emotional problems
  • alcohol consumption >7 beverages/week

Treatment and study plan

control snack

Other

Isovolumetric (238.4g) gel snack prepared by real fruits (186.2kcal)

Maltodextrin snack

Other

Isovolumetric (238.4g) gel snack with maltodextrin (271.8kcal)

Whey protein snack

Other

Isovolumetric (238.4g) gel snack with whey protein (201.8kcal)

Oat snack

Other

Isovolumetric (238.4g) gel snack with oats and maltodextrin (275.8kcal)

Coconut oil snack

Other

Isovolumetric (238.4g) gel snack with coconut oil (276.4kcal)

Snack skipping

Other

no snack

Primary outcomes

  1. Subjective Appetite

    Time frame: Change from baseline over 120 minutes

    Participants completed subjective ratings on appetite (e.g., desire to eat, hunger, fullness, prospective food consumption) and well-being at baseline (0 min), 15, 30, 45, 60, 90, and 120 min after snack consumption, as well as immediately following lunch.

Secondary outcomes

  1. Blood Glucose Response

    Time frame: Change from baseline over 120 minutes

    Blood was collected at baseline (0min), 15, 30, 45, 60, 90, and 120 min after snack consumption, as well as immediately following lunch to observe glycemic responses to gel snacks

  2. Blood Insulin Response

    Time frame: Change from baseline over 120 minutes

    Blood was collected at baseline (0 min), 15, 30, 45, 60, 90, and 120 min after meal consumption, as well as immediately following lunch, to observe insulin responses to gel snacks

  3. Food Intake

    Time frame: 30 min

    Participants consumed an ad libitum pizza lunch at 120 minutes

Sponsors and collaborators

Lead sponsor

Toronto Metropolitan University

Other

Collaborators

  • The Hershey Company

Registry information

Official study title

The Effect of Mid-Morning Gel Snacks on Subjective Appetite, Glycemic and Insulin Responses, and Food Intake in Healthy Adults

Important dates

Study start
2016
Primary completion
2016
Study completion
2016
First posted
Jul 5, 2017
Registry last updated
Jul 5, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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