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Completed

NCT Number: NCT07444671

Impact of Time-restricted Eating on Sleep, Glucose and Insulin Sensitivity

The purpose of this research study is to see how the timing of eating impacts participants sleep and how the body responds to sugar.

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Key information

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Sleep and Metabolism Laboratory

Fort Collins, Colorado, 80523, United States

About this study

This research study is aimed to answer how the timing of eating impacts participants sleep and how the body responds to sugar. Participants must be healthy and between the ages of 18-65 to join . This research study will take 2 weeks of outpatient monitoring, and 2 different nights staying in the Sleep and Metabolism Lab. There are some risks to participating in this study, like hunger, skin irritation, discomfort with blood draws, and uncomfortableness while being observed. The investigators hope that this research will benefit the knowledge learned about circadian rhythms and metabolic disease and how the timing of eating affects these things.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy adult men and women ages 18-65
  • habitual sleep duration between 7-9.25 hours
  • lived at altitude for at least 3 months.

Exclusion criteria

  • Diagnosed acute or chronic physical or psychiatric disorders;
  • diagnosed sleep disorders;
  • not participating in another research study concurrently which could increase risks, such as those involving medication or blood sampling;
  • shiftwork in the 6 months before the study; travel more then one time zone three weeks prior to the study;
  • blood donation 30 days prior to the first study visit;
  • illicit drug use, prescribed medication use (excluding over the counter products) 30 days prior to the study visit;
  • everyday nicotine use;
  • regular consumption of over 400mg caffeine per day in the past month; and consumption of over 14 alcoholic beverages a week, or more than 4 alcoholic beverages in a single day over the past month for men and consumption of over 7 alcoholic beverages a week, or more than 3 alcoholic beverages in a single day over the past month for women.

Treatment and study plan

Time restricted eating

Other

For the week between the first and second overnight stay participants will be scheduled to eat a normal food quantity, but in a shorter period of time based on timing discussed with study staff. Typically, this will mean they will stop eating sometime in the afternoon and not eat again until breakfast the following day.

Control eating

Other

Participants consume a normal eating schedule across the day.

Primary outcomes

  1. 24 hour Continuous Glucose Monitoring (Average glucose)

    Time frame: 2 weeks

    Participants will wear a continuous glucose monitor for 2 weeks. Week 1 will be compared to week 2.

  2. Oral glucose tolerance test (2 hour glucose)

    Time frame: 2 weeks

    Participants will complete an oral glucose tolerance test on 2 occasions (end of week 1 and end of week 2)

Sponsors and collaborators

Lead sponsor

Colorado State University

Other

Registry information

Important dates

Study start
2018
Primary completion
2021
Study completion
2021
First posted
Mar 3, 2026
Registry last updated
Mar 4, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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