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Completed

NCT Number: NCT05908201

Effects of Early Time Restricted Eating on Muscle Performance in Resistance Trained Individuals

A randomized controlled trial to determine the effectiveness of early time-restricted eating on muscle performance and body composition in active, resistance trained adults. Two parallel groups will be randomly assigned to either the early time-restricted eating or a control group. All participants will be asked to maintain their usual exercise routines during the 6 week intervention period. Muscle strength and endurance are the primary outcomes. Body composition (body weight, fat mass, fat-free mass and percent body fat), hunger and satiety ratings, sleep quality, energy intake, diet quality, macronutrient composition and adherence are secondary outcome measures.

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Key information

Conditions

Time Restricted Eating Behavior Fasting Feeding Behavior Intermittent Fasting

Age range

18 year–50 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Department of Nutrition and Hospitality Management, University of Mississippi

University, Mississippi, 38677, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adults between 18 - 50 years
  • Performing resistance training at least twice per week (for ≥1 yr)
  • BMI ≥ 18.5

Exclusion criteria

  • Currently sedentary or not engaged in resistance training.
  • Major surgeries in muscles/joints during the past 3 months
  • BMI < 18.5
  • Ineligible to engage in physical activity according to 2022 Physical Activity Readiness Questionnaire for everyone (PAR-Q+)
  • Take anabolic steroids or on hormone replacement therapy.
  • Current smoker.
  • Following restrictive diets (Vegan, vegetarian, intermittent fasting, Paleo, calorie restriction, keto/ low carbohydrate diet or any other restrictive diets)
  • Active cancer or cancer requiring treatment in the past 2 years (except non-melanoma skin cancer).
  • Musculoskeletal disorders
  • Diagnosed with cardiovascular disease including myocardial infarction, heart surgery, heart failure and had a heart transplant.
  • Have pacemaker or metal implants
  • Diagnosed diabetes (type 1 or 2).
  • Diagnosed hypertension or high blood pressure (>130/90).
  • Diagnosed eating disorder or score ≥ 20 on Eating Attitudes Test -26 (EAT26) survey
  • Missing limbs/ have prosthetics
  • Had surgery in joints/muscle in the past year.
  • Received medical advise against exercising due to medical reasons.
  • On medication for conditions related to the thyroid gland
  • Unwilling to commit for a 7-week study
  • Likely to move away from participating clinic before trial completed
  • Unable or unwilling to give informed consent
  • Another household member is a participant or staff member in the trial
  • Unwilling to accept treatment assignment by randomization
  • Current or anticipated participation in another intervention research project that would interfere with the intervention offered in the trial
  • Pregnant or < 6 months since giving birth.
  • Any other condition which, in opinion of investigators, that would adversely affect conduct of the trial.

Treatment and study plan

Early Time Restricted Eating

Behavioral

The intervention group will eat in a prescribed daily feeding window (9am-5pm) and follow their normal exercise and resistance training routines. We will allow up till +/-1 hour for the eating window start and end times while aiming for an 8 hour eating window.

Primary outcomes

  1. Muscular strength

    Time frame: 6-weeks

    Pre and post intervention testing of muscular strength using one-rep max

  2. Muscular endurance

    Time frame: 6-weeks

    Pre and post intervention testing of muscular endurance using barbell bench press and squat.

Secondary outcomes

  1. Body weight (kg)

    Time frame: 6-weeks

    Pre and post intervention measures of body weight.

  2. Hunger and satiety

    Time frame: 6-weeks

    Pre and post intervention subjective measure of hunger and satiety with the use of a Hunger and Satiety Visual Analog Scale (minimum value zero, maximum value 10). Higher the score, the more hungry/ less satiated one is.

  3. Sleep quality

    Time frame: 6-weeks

    Pre and post intervention measure of subjective sleep quality by use of Pittsburgh Sleep Quality Scale. (each question can be scored from 0-3, then an aggregate score of the whole survey can range from 0-21; The higher the score the worst the sleep quality).

  4. Total calorie intake

    Time frame: 6-weeks

    Pre and post intervention measurements of calorie intake based on 24-hour food recall survey using the Automated Self-Administered 24-hour (ASA24) software.

  5. Diet Quality

    Time frame: 6-weeks

    Pre and post intervention measurements of diet quality based on 24-hour food recall survey using the ASA24 software and Healthy Eating Index.

  6. Diet macronutrient composition

    Time frame: 6-weeks

    Pre and post intervention measurements of macronutrients based on 24-hour food recall survey using the ASA24 software.

  7. Adherence

    Time frame: 6-weeks

    Percent of days during the 6-week trial when eTRE was adhered to as recommended. This will be recorded by the participants daily throughout the entire study.

  8. Fat mass

    Time frame: 6-weeks

    Pre and post intervention measurements of body fat mass (kg).

  9. Fat-free mass

    Time frame: 6-weeks

    pre and post intervention measurements of body fat-free mass (kg).

  10. Body fat percentage

    Time frame: 6-weeks

    Pre and post intervention measurements of body fat percentage.

Sponsors and collaborators

Lead sponsor

University of Mississippi, Oxford

Other

Registry information

Official study title

Effects of 6-weeks of Early Time Restricted Eating on Muscle Performance in Resistance Trained Individuals

Important dates

Study start
2023
Primary completion
2023
Study completion
2023
First posted
Jun 18, 2023
Registry last updated
Jun 23, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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