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NCT Number: NCT07545525

HPV Testing as a Prevention of Cervical Dysplasia and Cancer Before Planned Subtotal Hysterectomy

Patients indicated for subtotal hysterectomy will be tested for High risk HPV and if the result is positive will undergo expert colposcopy and conisation if not indicated otherwise at the time of subtotal hysterectomy

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Key information

Conditions

Cervical Cancer Screening Human Papilloma Virus (HPV)

Age range

18 year and older

Sex eligibility

Female

Study type

Observational

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • age over 18
  • indication for subtotal hysterectomy
  • consent to provide conisation in case the HPV test result is positive

Exclusion criteria

  • negative HPV test in the last 3 years

Treatment and study plan

Primary outcomes

  1. Benefit of addition of HPV DNA testing before subtotal hysterectomy

    Time frame: 3 years

    Prevalence of HPV positivity in the tested cohort (patients indicated for subtotal hysterectomy).

    Prevalence of HPV (other than HPV 16 and 18) positivity in the tested cohort (patients indicated for subtotal hysterectomy).

    Prevalence of abnormal oncological cytology result and correlation to HPV result in the tested cohort (patients indicated for subtotal hysterectomy).

    Prevalence of cervical intraepithelial leasions in patients who underwent cone biopsy with the subtotal hysterectomy.

    Prevalence of high grade cervical intraepithelial leasions in patients who underwent cone biopsy with the subtotal hysterectomy.

    Rate of HPV negativity 6 months after cone biopsy.

Study contacts

Contact information is provided by the study sponsor or research team.

Tomas Fučík, M.D.

CONTACT

[email protected]

724188696 ext. +420

Sponsors and collaborators

Lead sponsor

General University Hospital, Prague

Other

Registry information

Official study title

HPV Testing as a Prevention of Cervical Dysplasia and Cervical Cancer Before Planned Subtotal Hysterectomy

Important dates

Study start
2026
Primary completion
2028
Study completion
2029
First posted
Apr 22, 2026
Registry last updated
Apr 22, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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