Healthy Oils for Women (HOW Study)

The long-term goal is to develop effective and novel dietary and lifestyle strategies to reduce the progression of metabolic syndrome to chronic diseases such as coronary heart disease. The rationale for conducting this research study is that there are few effective strategies that target changes in body composition and metabolism as a means to attenuate metabolic syndrome. The investigators plan to test the central hypothesis and accomplish the overall objective of this research by pursuing the following three specific aims.

Specific Aim 1: Quantify the extent that linoleic acid reduces trunk adipose mass in women with metabolic syndrome.

Specific Aim 2: Measure changes in visceral adipose tissue

Specific Aim 3: Determine the time-dependent effect of linoleic acid to increase adiponectin levels.

Inclusion criteria

• Female
• Post-menopausal (cessation of menses ≥12 months)
• Age ≥ 50 and ≤ 69 years
• At Least one of the following metabolic syndrome criteria

• Elevated triglycerides (>150mg/dl)
• Reduced HDL-C (<50mg/dl)
• Elevated blood pressure (>130mm Hg systolic or > 85 mm Hg diastolic)
• Elevated blood glucose (>100mg/dl and <126mg/dl)
• Obese (BMI ≥ 30 kg/m² and ≤ 55 kg/m²)

• Stable medical therapy for past 3 months
• Stable body weight (within ± 2 kg) for past 3 months
• Waist circumference >88cm (35 inches)

Exclusion criteria

• Substance abuse
• Current/previous diagnosis of type 2 diabetes or fasting blood glucose ≥126 mg/dL
• Current use of medications or supplements known to affect body composition
• Current or previous use of oral hypoglycemic agents or exogenous insulin.
• Impaired cognitive function
• Current or previous diagnosis of renal, heart, or circulatory disease
• Gastrointestinal diseases or disorders