Gonadal Function in Thalassemic Patient

Patient with transfusion depandant beta thalassemia with accumulation of iron in their body affect pituitary gland and gonades lead to impaired their functions .

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Key information

Conditions

Thalassemia Majors (Beta-Thalassemia Major) Anemia Anemia, Hemolytic Anemia, Hemolytic, Congenital Congenital, Hereditary, and Neonatal Diseases and Abnormalities Genetic Diseases, Inborn Hematologic Diseases Hemic and Lymphatic Diseases Hemoglobinopathies Thalassemia beta-Thalassemia

Age range

10 year–18 year

Sex eligibility

Male

Study type

Observational

About this study

detection of any abnormalities in pituitary gland hormones ( FSH , LH , serum prolactin ) gonadal hormones ( serum testesterone , antimullerian hormone , INSL3 , inhibin B hormone )

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

transfusion depandant beta thalassemia
age 10 to 18 year old age

Exclusion criteria

age below 10 year old age or above 18 year old age
associated with another disease

Treatment and study plan

serum inhibin B serum INSL3 serum AMH

Diagnostic Test

transfusion depandant beta thalassemia with measure gonadal function serum INSL3 serum inhibin B serum AMH

Primary outcomes

gonadal function in transfusion depandant beta thalassemia

Time frame: through study completion, an average of 1 year

gonadal function assessment by Inhibin B hormone, INSL3 , serum testesterone that analysed in patient with age 10 - 18 year old for early detection of any abnormality

Study contacts

Contact information is provided by the study sponsor or research team.

Ahmed Ahmed Moniur Hegab, Doctor

CONTACT

[email protected]

+201158744246

Hager Saadeldin saadeldin, pediatric resident

CONTACT

[email protected]

+201065099621

Sponsors and collaborators

Lead sponsor

Sohag University

Other

Registry information

Official study title

Gonadal Function in Boys With Transfusion Depandant Beta Thalassemia

Important dates

Study start: 2025
Primary completion: 2026
Study completion: 2026
First posted: Dec 17, 2025
Registry last updated: Dec 17, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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