geniculaR Artery eMBolization for Knee Osteoarthritis (RAMBO) Registry

The goal of this observational study (prospective registry) is to collect long-term real-world data on the effectiveness and safety of genicular artery embolization (GAE) for knee osteoarthritis in adults aged 18 years or older with symptomatic KOA that has not responded to medical therapy.

The main questions it aims to answer are:

1. Does GAE lead to sustained improvement in pain (WOMAC, VAS) and quality-of-life scores over 12-36 months? 2. What patient or procedural factors are associated with better outcomes after GAE?

Participants will:

* Undergo GAE as part of their routine clinical care. * Complete clinical follow-up assessments at 1, 3, 6, 12, 18, 24, and 36 months after treatment, including symptom and quality-of-life questionnaires. * Have safety outcomes tracked according to Society of Interventional Radiology guidelines.

There is no comparison group; results will be analyzed to identify predictors of success and inform best practices for patient selection and treatment.

Recruiting

Interested in participating?

Request Info

Key information

Conditions

Knee Osteoarthristis Arthritis Joint Diseases Musculoskeletal Diseases Osteoarthritis Osteoarthritis, Knee Rheumatic Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Joint and Vascular Institute

Libertyville, Illinois, 60048, United States

Location status: Recruiting

Location contact

Layth Alkhani

CONTACT

[email protected]

847-584-3959

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Adults (≥18 years) with symptomatic KOA refractory to medical therapy, referred for GAE.

Exclusion criteria

Pregnancy, coagulopathy, severe comorbidities, or inability to consent.

Treatment and study plan

Genicular Artery Embolization

Procedure

Genicular Artery Embolization (GAE) is a minimally invasive, image-guided procedure in which embolic agents are delivered into hyperemic genicular arteries to reduce synovial inflammation and knee pain from osteoarthritis.

Primary outcomes

Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC)

Time frame: 5 years of enrollment/patient

The investigators will describe differences in pain response with Genicular Artery Embolization (GAE) compared to a sham procedure when treating medically refractory mild to moderate Knee Osteoarthritis (KOA) at 12 months as measured by the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Pain subscale score. A higher score index a higher pain level while a lower score indicates lower pain levels. The score range is 0 to 96.

Sponsors and collaborators

Lead sponsor

Joint & Vascular Institute

Industry

Registry information

Official study title

Creation Of a Prospective Registry For Genicular Artery Embolization At The Joint & Vascular Institute

Acronym: RAMBO

Important dates

Study start: 2025
Primary completion: 2030
Study completion: 2030
First posted: Feb 2, 2026
Registry last updated: Jun 12, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Recruiting