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NCT Number: NCT07402408

Blood Flow Restriction Training in Knee Osteoarthritic Patients

The aim of this study was to compare the effect of band tissue flossing method and traditional cuff method for blood flow restriction training on pain, range of motion, muscle strength and functional status in patients with knee osteoarthritis. Symptoms of this condition limit patient's ability to perform high load strengthening. Blood flow restraining training allows strengthening with lower loads. 46 subjects will be divided in two groups, 23 subjects in each group. knee extension and knee press exercises will be performed. In group A floss band was tied on thigh and in group B pneumatic cuff was applied on thigh. 40-60 years individual with knee osteoarthritis will be included. outcome measures will be assessed at baseline, after 1st session, after 2nd week and after 4th week.

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Key information

Age range

40 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Pakistan Institute of Medical Sciences (P.I.M.S.)

Islamabad, Federal, 44000, Pakistan

Location status: Recruiting

Location contact

Dua Ejaz Saigaal, MS-PT*

SUB_INVESTIGATOR

Muhammad Affan Iqbal, PhD*

CONTACT

[email protected]

03336754837

Muhammad Affan Iqbal, PhD*

PRINCIPAL_INVESTIGATOR

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age 40-60 years
  • Pain more than or equal to 3 on NPRS
  • Range of motion ≤ 100-degree flexion and ≤ 0-degree extension
  • Those who have knee osteoarthritis, according to KL (Grade 1 and 2)
  • Genders: Male and Female

Exclusion criteria

  • Cardiovascular condition e.g., hypertension, thromboembolism, lymphatic diseases etc.
  • Muscle/tendon/ ligament injuries
  • Any surgery, skin infection, trauma, pregnancy, fracture and fall
  • Patient with intra articular steroidal therapy with in last 6 months
  • Patient unwilling to participate and comply with the study session

Treatment and study plan

Blood flow restriction training with Floss band

Other

seated knee extension exercise and knee press exercises (4 sets; repetitions: 30,15,15,15) performed for four weeks with three sessions per week. Exercises performed with 20% of one repetition maximum. Floss band was tied at proximal thigh with 50% stretch in proximal to distal direction starting from above the patella and moving towards groin.

Blood flow restriction training with pneumatic cuff

Other

seated knee extension exercises and knee press exercises (4 sets; repetitions: 30,15,15,15) performed for four weeks with three sessions per week. Exercises performed with 20% of one repetition maximum. Clinical cuff was tied at proximal thigh with 40% of limb occlusion pressure.

Primary outcomes

  1. Numeric Pain Rating Scale (NPRS)

    Time frame: 4th week

    Changes from baseline will be assessed using NPRS scale. It is a one-dimensional measure of pain severity in adults including those suffering from chronic pain. Scale has ratings of 0 to 10, with higher points indicating higher levels of pain severity. it is a valid tool for assessing pain in knee OA patients.

Secondary outcomes

  1. Knee Flexion Range of motion

    Time frame: 4th week

    Changes in knee flexion range of motion from baseline will be assessed using universal goniometer. Goniometer is the most common instrument utilized for measuring available range of motion. Universal Goniometer Comes in two variations one is short arm whereas one is long arm. The one with short arm is used for smaller joints like the wrist, elbow, or ankle. On the other hand, long arm goniometers provide greater accuracy for knee and hip joints which have long bones acting as levers

  2. Knee Extension Range of Motion

    Time frame: 4th week

    Changes from baseline in knee extension range of motion will be assessed with goniometer. It is the most common instrument utilized for measuring available range of motion. Universal Goniometer Comes in two variations one is short arm whereas one is long arm. The one with short arm is used for smaller joints like the wrist, elbow, or ankle. On the other hand, long arm goniometers provide greater accuracy for knee and hip joints which have long bones acting as levers

  3. Quadriceps strength (dynamometer)

    Time frame: 4th week

    Quadriceps muscle strength changes from baseline will be assessed using crane scale dynamometer. Participant sits in chair with hips and knees flexed to 90 degrees. The hook of dynamometer is secured to the ankle with a strap, while from behind the dynamometer is fixed to leg of chair to provide a stable anchor. As the participant performs knee extension the force generated is recorded in newtons or kilograms. It is a valid and reliable tool for assessing strength of knee extensors.

  4. Western Ontario and McMaster Universities (WOMAC) index

    Time frame: 4th week

    WOMAC index was developed in order to fill the need for an outcome instrument that could be responsive to change in OA-related symptoms following a clinical trial. It includes five questions about pain, two about stiffness, and seventeen on degree of disability of activities of daily living. total score is converted to percentage. higher scores mean severe symptoms.

  5. 30 Second Sit to Stand Test (STS)

    Time frame: 4th week

    The 30 Second Sit to Stand Test (STS) is also known as 30 Second Chair Stand Test (30CST), was initially designed for testing leg strength and endurance in older adults. It is used for adults of 18-64 years, older adults (65 years and above), and people with osteoarthritis. A person stands up and sits down five times as quickly and safely as possible, with their arms folded across their chest, A longer time indicates weaker leg strength and a greater risk of falls. It records the number of times a person can sit and stand within 30 seconds

  6. Timed Up and Go Test (TUG)

    Time frame: 4th week

    This test is for assessing ambulatory transition in knee OA patients. For this test participant stands from armed chair, walks with comfortable pace to a line 3 m away, at end point turns, and returns to sitting position in chair. Participant can't use walking aid during task. Time is recorded in which task is done.

Study contacts

Contact information is provided by the study sponsor or research team.

Imran Amjad, PhD

CONTACT

[email protected]

03324390125

Sponsors and collaborators

Lead sponsor

Riphah International University

Other

Registry information

Official study title

Comparison of Band Tissue Flossing Method and Traditional Cuff Method for Blood Flow Restriction Training in Patients With Knee Osteoarthritis

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Feb 11, 2026
Registry last updated
Jul 20, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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