Skip to main content
OpenTrials
Recruiting

NCT Number: NCT05747976

Genetic Disorders of Obesity Program Database

This study collects data on children with severe, early-onset obesity.

Recruiting

Interested in participating?

Request Info

Key information

Conditions

Obesity, Childhood Body Weight Congenital, Hereditary, and Neonatal Diseases and Abnormalities Genetic Disease Genetic Diseases, Inborn Nutrition Disorders Nutritional and Metabolic Diseases Obesity Overnutrition Overweight Pathological Conditions, Signs and Symptoms Pediatric Obesity Signs and Symptoms

Sex eligibility

All sexes

Study type

Observational

Primary location

Baylor College of Medicine

Houston, Texas, 77030, United States

Location status: Recruiting

Location contact

Citrine Elatrash

CONTACT

[email protected]

Stephanie Sisley, MD

PRINCIPAL_INVESTIGATOR

About this study

Children and adolescents who have suffered from severe weight gain prior to 5 years of age and who are seen in the Genetic Disorders of Obesity Program at Texas Children are asked to participate in a prospective, observational study. The investigators collect demographic information, body measurements, medical/family history, as well as other questionnaires. Additionally, genetic information, medical lab results, and responses to treatment options are collected. The goal of the study is to determine if the investigators can better understand which children would benefit from testing and further workup as well as to understand how obesity develops in these children and adolescents.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • For individuals 2 years and older, BMI > 97 percentile
  • For individuals < 2 years old, weight-to-length ratio > 95th percentile

Exclusion criteria

  • No other exclusion criteria

Treatment and study plan

Primary outcomes

  1. Prevalence of genetic causes of severe, early-onset obesity

    Time frame: through study completion, an average of 10 years

    We will measure the number of genetic variants identified in clinical testing

Secondary outcomes

  1. Change in BMI over time

    Time frame: through participant completion, an average of 2 years

    BMI in kg/m2 will be documented over time. BMI is calculated using weight and height

Study contacts

Contact information is provided by the study sponsor or research team.

Stephanie Sisley, MD

CONTACT

[email protected]

713-798-0391

Sponsors and collaborators

Lead sponsor

Baylor College of Medicine

Other

Registry information

Acronym: GDOP

Important dates

Study start
2020
Primary completion
2030
Study completion
2030
First posted
Feb 28, 2023
Registry last updated
May 12, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.