Gammaglobulins Level is Predictive Factor of Evolution in Sarcoidosis

Evaluation of the rate of achievement of serum protein electrophoresis (PPE) in diagnosis in a retrospective cohort of patients at Rennes University Hospital

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Key information

Conditions

Sarcoidosis Hemic and Lymphatic Diseases Hypersensitivity Hypersensitivity, Delayed Immune System Diseases Lymphatic Diseases Lymphoproliferative Disorders

Sex eligibility

All sexes

Study type

Observational

Primary location

CHU de Rennes

Rennes, 35033, France

About this study

In 50% of cases, sarcoidosis is associated with polyclonal hypergammaglobulinemia. The other forms have a normal gamma globulin level.

The level of gamma globulinemia has not yet been studied as an evolutionary predictive factor. Furthermore, there are disseminated granulomatoses sharing common characteristics with sarcoidosis, associated with Common Variable Immunodeficiency deficit (DICV) type Primary Immunodeficiency syndrome (DIP), thus occurring in hypogammaglobulinemic patients.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients newly diagnosed with sarcoidosis

Exclusion criteria

Comorbidity responsible for a change in the level of gamma globulin
Other etiology of granulomatosis

Treatment and study plan

Analysis of gamma globulin

Biological

Electrophoresis of proteins

Primary outcomes

Study of gamma globulin level present in the blood at the time of diagnosis of sarcoidosis on disease activity

Time frame: Day 1

Electrophoresis rates of serum proteins
Study of gamma globulin level present in the blood at the time of diagnosis of sarcoidosis on the course of the disease

Time frame: Day 1

Electrophoresis rates of serum proteins

Sponsors and collaborators

Lead sponsor

Rennes University Hospital

Other

Registry information

Acronym: GAMES

Important dates

Study start: 2017
Primary completion: 2017
Study completion: 2017
First posted: Aug 23, 2017
Registry last updated: Apr 12, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed