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Completed

NCT Number: NCT07094646

Full Assessment of Clinical Transfusion Support

This study looks at why some children develop very severe anemia that leads to a blood transfusion. It also checks for diseases in the blood they receive. Researchers are using small samples of dried blood (called dried blood spots) from both the children and the donated blood to find out what might be causing the anemia.

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Key information

Conditions

Sickle Cell Anemia Anemia Anemia, Hemolytic Anemia, Hemolytic, Congenital Anemia, Sickle Cell Blood Transfusion Congenital, Hereditary, and Neonatal Diseases and Abnormalities Genetic Diseases, Inborn Hematologic Diseases Hemic and Lymphatic Diseases Hemoglobinopathies Malaria Parasitaemia

Sex eligibility

All sexes

Study type

Observational

Primary location

Jinja Regional Referral Hospital (JRRH)

Jinja, Uganda

About this study

This study includes children at Jinja Regional Referral Hospital (Jinja, Uganda) who need a blood transfusion, whether they are in the clinic, emergency room, or children's ward. After doctors finish the usual blood tests, a small sample of leftover blood will be saved on a special card (called a dried blood spot). The same will be done for all blood transfused during the study. These samples will be frozen and later sent to Cincinnati Children's Hospital for testing.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Children receiving a blood transfusion in Eastern Uganda at Jinja Regional Referral Hospital.

Exclusion criteria

  • If receiving a blood transfusion, refusal or inability to sign an informed consent.

Treatment and study plan

Primary outcomes

  1. Frequency of Sickle Cell Anemia

    Time frame: At enrollment.

    How common sickle cell anemia is in children who need a blood transfusion in Eastern Uganda.

Secondary outcomes

  1. Frequency of Malaria Parasitemia

    Time frame: At enrollment.

    How common malaria parasitemia in children needing blood transfusions in Eastern Uganda.

  2. Frequency of Iron Deficiency

    Time frame: At enrollment

    How often people who get blood transfusions have low iron levels, and the iron levels in the blood that is donated and used for transfusions

  3. Blood Group Markers

    Time frame: At enrollment.

    Checking to ensure safe blood matches from donated blood and people receiving blood transfusions.

Sponsors and collaborators

Lead sponsor

Children's Hospital Medical Center, Cincinnati

Other

Registry information

Official study title

An Assessment of Hematologic Diseases Among Blood Transfusion Recipients and Donated Units at a Pediatric Regional Referral Hospital in Uganda

Acronym: FACTS

Important dates

Study start
2023
Primary completion
2024
Study completion
2024
First posted
Jul 30, 2025
Registry last updated
Jul 30, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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