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Completed

NCT Number: NCT00725218

Flurbiprofen Axetil for Uterine Contraction Pain

Uterine contraction pain is a common problem after abortion. Optimal analgesic for such suffering is still needed to be guaranteed. Flurbiprofen Axetil is a target-distributable non-steroidal anti-inflammatory drug (NSAID) functioning via block the synthesis of prostaglandin E (PGE). The investigators hypothesized that Flurbiprofen Axetil could suppress the uterine contraction pain after abortion effectively.

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Key information

Conditions

Postoperative Pain Agnosia Nervous System Diseases Neurobehavioral Manifestations Neurologic Manifestations Pain Pain, Postoperative Pathologic Processes Pathological Conditions, Signs and Symptoms Perceptual Disorders Postoperative Complications Signs and Symptoms

Age range

19 year–45 year

Sex eligibility

Female

Study type

Interventional

Phase

Phase 4

Primary location

Nanjing Maternal and Child Health Care Hospital

Nanjing, Jiangsu, 210004, China

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • ASA status I-II
  • Performing abortion operation (medical- or drug-induced
  • Requiring painless abortion

Exclusion criteria

  • < 19yrs, and >= 45yrs
  • History of central active drugs administration
  • Drug abuse
  • Hypertension
  • Diabetes
  • Any other chronic diseases
  • Allergy to the study drugs
  • Habit of over-volume alcohol drinking
  • Records of history of centrally active drug use and psychiatry
  • Any organic disorders

Treatment and study plan

Saline

Drug

Saline 5 ml injection 10 min prior to propofol administration.

Other names: Ringer's solution

Flurbiprofen Axetil

Drug

Flurbiprofen Axetil 50 mg in 5 ml injection 10min prior to propofol administration.

Other names: KaiFen

Primary outcomes

  1. VAS pain scorings

    Time frame: At the end of the operation, 0,5,15,30,60min after operation

Secondary outcomes

  1. Anesthetic consumptions

    Time frame: At the end of the operation

  2. Overall VAS satisfaction scorings with analgesia

    Time frame: At the end of the study

  3. Side effects

    Time frame: During the whole period of the study

  4. Volume of bleeding

    Time frame: At the end of the study

Sponsors and collaborators

Lead sponsor

Nanjing Medical University

Other

Registry information

Official study title

Phase IV Study of Flurbiprofen Axetil for Uterine Contraction Pain After Abortion

Acronym: FAUCOP

Important dates

Study start
2008
Primary completion
2008
Study completion
2008
First posted
Jul 30, 2008
Registry last updated
Aug 6, 2008

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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