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Completed

NCT Number: NCT07724678

Comparison of Combined (Superficial and Deep) and Isolated Deep Serratus Anterior Plane Blocks After Breast Surgery

The main purpose of this study is to compare the effectiveness of two different regional anesthesia techniques for pain management after oncological breast surgeries. The researchers will compare the combined (superficial and deep) serratus anterior plane block with the deep serratus anterior plane block. The study aims to evaluate which method provides better postoperative pain relief, reduces the total consumption of opioid analgesics, and improves patient comfort

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Key information

Conditions

Breast Cancer Agnosia Breast Diseases Breast Neoplasms Neoplasms Neoplasms by Site Nervous System Diseases Neurobehavioral Manifestations Neurologic Manifestations Pain Pain Management After Surgery Pain, Postoperative Pathologic Processes Pathological Conditions, Signs and Symptoms Perceptual Disorders Postoperative Complications Postoperative Pain Signs and Symptoms Skin Diseases Skin and Connective Tissue Diseases

Age range

18 year–80 year

Sex eligibility

Female

Study type

Observational

Primary location

Ankara Training and Research Hospital

Altındağ, Ankara, 00000, Turkey (Türkiye)

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients aged 18-80 years.

Female patients with ASA physical status I, II, or III.

Patients scheduled for elective modified radical mastectomy or breast-conserving surgery.

Patients who provided written and verbal informed consent.

Exclusion criteria

Patients with ASA physical status IV-V.

Patients with a BMI ≥ 35 kg/m².

Patients with chronic pain, opioid/substance addiction, or long-term analgesic use.

Patients requiring emergency surgery.

Pregnant patients.

Known allergy to local anesthetics.

Severe cardiovascular, cerebrovascular, liver, or renal disease.

History of coagulopathy.

Infection at the injection site or systemic infection.

Patients who refuse the regional anesthesia technique, cannot speak the official language, or have mental disabilities/inability to cooperate.

Patients with a history of previous breast surgery or those scheduled for bilateral operations.

Treatment and study plan

Primary outcomes

  1. Visual Analog Scale (VAS) Scores for Postoperative Pain

    Time frame: Postoperative 24 hours.

    Assessment of postoperative pain using the Visual Analog Scale (VAS) (minimum score: 0, maximum score: 10, where higher scores indicate worse outcome).

Secondary outcomes

  1. Total Tramadol Consumption

    Time frame: Postoperative 24 hours.

    Total amount of tramadol consumed by the patient as rescue analgesia.

  2. Need for rescue analgesia

    Time frame: Postoperative 24 hours.

    Requirement for additional analgesic medications beyond the standard protocol.

  3. Time to first rescue analgesia

    Time frame: Postoperative 24 hours.

    Time elapsed from the end of surgery until the first request for rescue analgesia.

  4. Postoperative nausea and vomiting (PONV) scores

    Time frame: Postoperative 24 hours.

    Assessment of postoperative nausea and vomiting severity.

  5. Patient satisfaction

    Time frame: Postoperative 24 hours.

    Patient satisfaction level regarding the pain management technique.

  6. Block-related complications

    Time frame: Postoperative 24 hours.

    Incidence of potential complications related to the block technique (e.g., hematoma, infection, local anesthetic toxicity).

Sponsors and collaborators

Lead sponsor

SBU Ankara Egitim ve Arastirma Hastanesi

Other

Registry information

Official study title

Investigation of the Effectiveness of Ultrasonography-Guided Deep Serratus Anterior Plane Block and Combined Superficial and Deep Serratus Anterior Plane Block on Postoperative Pain in Patients Undergoing Modified Radical Mastectomy and Breast-Conserving Surgery

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Jul 24, 2026
Registry last updated
Jul 24, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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