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Enrolling by Invitation

NCT Number: NCT07259356

Feasibility and Safety of Blood-Flow-Restriction Training in Patients With Hemophilia

In the course of a cross-over study design, 12 patients with hemophilic arthropathy will perform a training load on the knee extensor muscles. The subjects will each perform one intervention with blood flow restriction and one with a Sham-BFR intervention.

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Key information

Conditions

Hemophilia Blood Coagulation Disorders Blood Coagulation Disorders, Inherited Coagulation Protein Disorders Congenital, Hereditary, and Neonatal Diseases and Abnormalities Genetic Diseases, Inborn Hematologic Diseases Hemic and Lymphatic Diseases Hemophilia A Hemorrhagic Disorders

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University Hospital Bonn

Bonn, North Rhine-Westphalia, 53127, Germany

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • patients with haemophilia
  • Ability for an exercise intervention

Exclusion criteria

  • Sickle Cell Anemia
  • Intravascular stents/bypasses
  • Open Wounds/Infections of the lower extremity

Treatment and study plan

Control

Device

Sham-BFR Exercise (20mmHg) while Leg Press Exercise (4 Sets, All out)

BFR Exercise (50% of the LOP) while Leg Press Exercise (4 Sets, All out)

Device

BFR Exercise (50% of the LOP) while Leg Press Exercise (4 Sets, All out)

Primary outcomes

  1. Pain threshold

    Time frame: Pre- (Baseline, before Exercise) to immediately Post-Intervention (after the exercise training intervention) and 24 hours after intervention

    Pain threshold measurement (PTT): The test determines the amount of pressure (in kg) over a given area in which a steadily increasing nonpainful pressure stimulus turns into a painful pressure sensation.

  2. Quality of Life Score

    Time frame: Pre- (Baseline, before Exercise) to immediately Post-Intervention (after the exercise training intervention) and 24 hours after intervention

    Hemophilia Joint Health Score

Sponsors and collaborators

Lead sponsor

University Hospital, Bonn

Other

Registry information

Official study title

Effect of Blood Flow Restriction Training on the Subjective Perception of Pain in Hemophilic Arthropathy of the Knee Joint

Important dates

Study start
2024
Primary completion
2025
Study completion
2026
First posted
Dec 2, 2025
Registry last updated
Dec 2, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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