Comparison of Upper Extremity Functional Performance in Hemophilic and Healthy Children

The goal of this observational study is to evaluate the functional performance of the upper extremity joints (scapula, shoulder, elbow, and wrist) in haemophilic children and compare muscle strength and ADL limitations with healthy children.

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Key information

Conditions

Hemophilia Blood Coagulation Disorders Blood Coagulation Disorders, Inherited Children Coagulation Protein Disorders Congenital, Hereditary, and Neonatal Diseases and Abnormalities Genetic Diseases, Inborn Hematologic Diseases Hemic and Lymphatic Diseases Hemophilia A Hemorrhagic Disorders Performance Strength Upper Extremity

Age range

7 year–17 year

Sex eligibility

Male

Study type

Observational

Primary location

Hacettepe Universit

Ankara, 06100, Turkey (Türkiye)

About this study

This study aims to evaluate the upper extremity functional performance, muscle strength, and daily living activity levels of hemophilic children and compare them with healthy children. The goal is to determine the effects of hemophilia on these children and contribute to the development of appropriate rehabilitation strategies. Parameters include explosive strength, isometric muscle strength, wrist grip strength, and functional exercise capacity. Additionally, the ADL-Glittre pediatric version test and Hemophilia Joint Health Score (HJHS) will be used to assess joint health and GYA performance. Muscle strength is crucial for hemophilic children to perform daily activities, and the relationship between muscle strength and GYA levels will be investigated. The project aims to guide the development of physiotherapy and rehabilitation strategies for hemophilic children and contribute to the literature by filling existing gaps, ultimately creating an important reference for healthcare professionals and families.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Diagnosed with Hemophilia A or B
Receiving prophylaxis treatment (a routine treatment)
Negative for inhibitors at the time of enrollment

Exclusion criteria

Positive for inhibitors at the time of enrollment
Acute elbow bleeding
History of acute muscle bleeding
History of surgery in any upper extremity joints
Having undergone radionuclide synovectomy

Treatment and study plan

Primary outcomes

Hemophilia Joint Health Score

Time frame: Through study completion, an average of 1 year

The Hemophilia Joint Health Score (HJHS) is a clinical tool used to assess joint health in individuals with hemophilia, focusing on major joints such as the knees, elbows, and ankles. It evaluates symptoms like pain, swelling, and range of motion restrictions, with a grading system that helps determine the severity of joint damage. The HJHS also considers joint function in daily activities, making it an essential tool for monitoring joint health and the progression of hemophilic arthropathy. It plays a vital role in both clinical management and research, helping guide treatment strategies and assess their effectiveness.

Secondary outcomes

Muscle Strength

Time frame: Through study completion, an average of 1 year

The Lafayette Handheld Dynamometer is a device used to measure upper extremity muscle strength in children with hemophilia. It assesses muscle strength under isometric conditions and is typically used to test the muscles around the shoulder, elbow, and wrist. The measurements aim to determine the maximum force exerted by the muscles, which is important for identifying potential reductions in muscle strength in individuals with hemophilia. This test is valuable for determining physical performance levels, planning treatment approaches, and guiding rehabilitation processes.

Sponsors and collaborators

Lead sponsor

Hacettepe University

Other

Registry information

Official study title

Comparison of Upper Extremity Functional Performance, Muscle Strength, and Activities of Daily Living Levels in Children with Hemophilia and Healthy Children

Important dates

Study start: 2024
Primary completion: 2026
Study completion: 2026
First posted: Feb 13, 2025
Registry last updated: Feb 13, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

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