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Completed

NCT Number: NCT01757093

Evaluation of Oxygen Consumption and Energy Expenditure During Spontaneous Breathing Trial.

The purpose of this study is to compare the oxygen consumption and energy expenditure during the spontaneous breathing trial.

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Key information

Conditions

Respiratory Failure Respiration Disorders Respiratory Insufficiency Respiratory Tract Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Hospital Das Clínicas Da Faculdade de Medicina de Ribeirão Preto -Universidade de São Paulo

Ribeirão Preto, São Paulo, 14049900, Brazil

About this study

Patients is going to submit to the 2 spontaneous breathing trial ( Automatic tube compensation plus continuous positive airway pressure and continuous positive airway pressure without automatic tube compensation. The oxygen consumption and energy expenditure is going to measure during the spontaneous breathing trial by indirect calorimetry.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • IMPROVEMENT OR RESOLUTION OF THE UNDERLYING CAUSE OF DISEASE
  • INTUBATED PATIENTS>24h
  • PaO2 GREATER THAN 60 mmHg WITH FiO2 LESS THAN 40%
  • PEEP=5 cmH2O

Exclusion criteria

  • CARDIOVASCULAR INSTABILITY
  • FEBRILE OR HYPOTHERMIA
  • CHEST DRAINAGE
  • RESPIRATORY RATE/TIDAL VOLUME RATIO GREATER THAN 105
  • PREGNANCY
  • FAIL IN THE SPONTANEOUS BREATHING TRIAL
  • LEAKS IN THE CIRCUIT
  • AGITATION
  • NOT ACCEPT PARTICIPATE IN THE STUDY

Treatment and study plan

Automatic Tube Compensation plus CPAP

Device

SPONTANEOUS BREATHING TRIAL WITH AUTOMATIC TUBE COMPENSATION plus CPAP

Other names: ATC+CPAP

Continuous Positive Airway Pressure

Device

SPONTANEOUS BREATHING TRIAL WITH CPAP

Primary outcomes

  1. Measurement of oxygen consumption through indirect calorimetry.

    Time frame: The measurement is during the spontaneous breathing trial, 30 minutes.

    Measurements using indirect calorimetry for determination of oxygen consumption

Secondary outcomes

  1. Measurement of energy expenditure through indirect calorimetry

    Time frame: The measurement is during the spontaneous breathing trial, 30 minutes.

    Measurement using indirect calorimetry for determination of energy expenditure.

Sponsors and collaborators

Lead sponsor

University of Sao Paulo

Other

Registry information

Official study title

Evaluation of Oxygen Consumption and Energy Expenditure During Spontaneous Breathing Trial - A Randomized Crossover Controled Trial.

Important dates

Study start
2012
Primary completion
2013
Study completion
2013
First posted
Dec 28, 2012
Registry last updated
Dec 2, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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