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Completed

NCT Number: NCT07602738

Evaluation of Liquorice Nanogel Versus Diode Laser as an Adjunctive Treatment for Patients With Periodontitis Stage Ⅲ.

Evaluation of the effect of liquorice nanogel versus diode laser on periodontitis stage Ⅲ clinically and microbiologically by molecular analysis of porphyromonas gingivalis using real time PCR.

Completed

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Key information

Conditions

Diode Laser Therapy Liquorice Nanogel Mouth Diseases Periodontal Disease Periodontal Diseases Stomatognathic Diseases

Age range

18 year–50 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 3

Primary location

Alazhar University for Girls

Cairo, Cairo Governorate, 00202, Egypt

About this study

Quantitative analysis technique using real time pcr (polymerase chain reaction) was done to detect presence of porphyromonas gingivalis. Pocket depth (PD), Plaque index (PI), gingival index (GI) and Clinical attachment level (CAL) were measured before work and after 3 months postoperatively.

Analysis was made from gingival crevicular fluid samples of the patients using gutta percha paper points.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patient had Periodontitis stage III with pocket depth ≥ 6mm; indicated for periodontal surgery or CAL ≥ 5mm.
  • Patient agreed to the surgical procedure and clinical trial.
  • Age ranged between 18-50 years old.

Exclusion criteria

  • 1: No previous drug was taken affecting bone metabolism. 2- Smoking. 3- Pregnant women and women with menopause. 4- Patients with psychological problems . 5- Patients with abnormal habits. 6- Patients with medical conditions as Diabetes or Hypertension.

Treatment and study plan

Liquorice Nanogel

Drug

Real Time pcr was chosen to detect 16s gene concentration for porphyromonas gingivalis bacteria that is specific for Periodontitis Stage 3.

diode laser

Drug

Real time Pcr was used to detect gene concentration 16s specific for porphyromonas gingivalis

Primary outcomes

  1. Quantitative analysis using real time pcr

    Time frame: 3 months

Sponsors and collaborators

Lead sponsor

Al-Azhar University

Other

Registry information

Acronym: Periodontology

Important dates

Study start
2024
Primary completion
2025
Study completion
2026
First posted
May 22, 2026
Registry last updated
May 22, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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