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OpenTrials
Completed

NCT Number: NCT07056257

Adjunct Use of Diode Laser Therapy and Omega 3 Gel in Local Drug Delivery Approach on The Treatment of Localized Aggressive Periodontitis

This study aims to evaluate and compare the effect of combination therapy between diode laser and omega3 gel in the local drug delivery approach as an adjunct to scaling and root planning on the management of localized aggressive periodontitis clinically and immunologically.

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Key information

Age range

18 year–35 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Tanta University

Tanta, El-Gharbia, 31527, Egypt

About this study

Periodontitis is a disease of the periodontium occurring in an otherwise healthy adolescent, which is characterized by a rapid loss of alveolar bone about more than one tooth of the permanent dentition.

The laser approach is an efficient and atraumatic technique to enhance its use for periodontal treatment. Within the limits of scientific data, treatment with diode laser and SRP showed a higher effect than SRP or laser alone.

Omega3 Polyunsaturated fatty acids (PUFA) have well recognized anti-inflammatory properties. They decrease inflammation through multiple pathways.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients diagnosed with localized aggressive periodontitis.
  • Patients must be medically free.
  • Optimal compliance as evidenced by no missed treatment appointments and a positive attitude to maintain oral hygiene.
  • Patients who are willing to participate in this study can enroll and complete it.

Exclusion criteria

  • Patients with generalized aggressive periodontitis. Patients are over 35 years old.
  • Pregnancy.
  • Patients had scaling and root planning or antibiotic therapy in the last 6 months.
  • Patients with hypersensitivity to fish oil.

Treatment and study plan

Scaling-root planning (SRP)

Procedure

Thirteen sites [scaling-root planning (SRP)] were used as a control group.

Scaling-root planning (SRP)+ laser therapy

Procedure

Thirteen sites [scaling-root planning (SRP)+ laser therapy with application of methyl cellulose gel at repeated times weekly for one month].

Scaling-root planning (SRP)+ omega 3 gel

Procedure

Thirteen sites [scaling-root planning (SRP) + omega 3 gel repeated time weekly for one month].

Scaling-root planning (SRP)+ laser therapy+ omega 3 gel

Procedure

Thirteen sites [combination therapy between scaling-root planning (SRP) + laser + omega 3 gel in repeated time weekly for one month].

Primary outcomes

  1. Pocket depth

    Time frame: 6 months post-procedure

    Probing pocket depth (PD) was recorded according to Ramfijord 1967.

Secondary outcomes

  1. Plaque score

    Time frame: 6 months post-procedure

    Plaque score was recorded according to Silness and loe 1964.

  2. Bleeding on probing

    Time frame: 6 months post-procedure

    Bleeding on probing (BOP) according to Ainamo and Bay 1975.

  3. Clinical attachment level loss

    Time frame: 6 months post-procedure

    Clinical attachment level loss (CAL) according to according to Ramfijord 1967.

Sponsors and collaborators

Lead sponsor

Tanta University

Other

Registry information

Official study title

The Effect of Adjunct Use of Diode Laser Therapy and Omega 3 Gel in Local Drug Delivery Approach on The Treatment of Localized Aggressive Periodontitis

Important dates

Study start
2022
Primary completion
2024
Study completion
2025
First posted
Jul 9, 2025
Registry last updated
Jul 9, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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