Electron Microscopic Examination of Iris Tissue in Buphthalmos

To revise the etiology of the primary congenital glaucoma in some infants.

Completed

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Key information

Conditions

Iris Diseases Congenital Abnormalities Congenital, Hereditary, and Neonatal Diseases and Abnormalities Eye Abnormalities Eye Diseases Glaucoma Glaucoma, Open-Angle Hydrophthalmos Infant, Newborn, Diseases Ocular Hypertension Uveal Diseases

Age range

1 month–9 month

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Assiut univercity

Asyut, Egypt

About this study

Combined trabeculotomy trabeculectomy with mitomycin C was done Electron microscopic examination of the peripheral iris tissue specimen was done in all cases.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

infants under age of 2 years
1ery glaucoma

Exclusion criteria

infants more than 2 years
2ery glaucoma
previous glaucoma surgery

Treatment and study plan

Combined trabeculotomy trabeculectomy with mitomycin C

Procedure

Combined trabeculotomy trabeculectomy with mitomycin C with histopathological examination of the peripheral iris tissue specimen of all cases

Primary outcomes

fibrovascular membrane over iris surface

Time frame: 6 months

angle closure by a fibrovascular tissue proliferation over the trabecular meshwork in the anterior chamber angle

Sponsors and collaborators

Lead sponsor

Assiut University

Other

Registry information

Important dates

Study start: 2024
Primary completion: 2025
Study completion: 2025
First posted: Jun 24, 2025
Registry last updated: Jun 24, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed