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OpenTrials
Completed

NCT Number: NCT05859646

Effects of Probiotics on Streptococcus Mutans ve Lactobacillus Spp

To evaluate the change of S. mutans and Lactobacillus spp. counts after all dental treatments were completed under general anesthesia and compare the groups in case of using probiotics and not using probiotics with the time for 6-months follow-up period.

Completed

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Key information

Conditions

Tooth Decay Dental Caries Probiotics Stomatognathic Diseases Streptococcus Mutans Tooth Demineralization Tooth Diseases

Age range

2 year–12 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Başkent University

Ankara, Cankaya, 06490, Turkey (Türkiye)

About this study

Fifthy-eight pediatric patients without any systemical diseases whose dental treatments were completed under general anesthesia were included in the study. The study was carried out as two-groups; Group A: Patients who started using probiotics after general anesthesia and Group B: Patients who did not use probiotics after general anesthesia. The counts of S. mutans and Lactobacillus spp. were determined by quantitative polymerase chain reaction (qPCR) by analysis of saliva samples taken from all patients on the day before the general anesthesia (T0), at 1-month (T1), 3-month (T2) and 6-month (T3) follow-up periods. The statistical significance level was accepted as p<0.05.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Every included child had at least 8 tooth with caries.

Exclusion criteria

  • Patients who would not be able to give saliva samples due to high anxiety or lack of saliva were not included in this study.

Treatment and study plan

Probiotic use

Dietary Supplement

Probiotics were used for 3 months and all participated patients were followed for 6 months.

Other names: Follow-up after general anesthesia

Primary outcomes

  1. S mutans count

    Time frame: 6 month

    CFU

  2. Lactobacillus spp count

    Time frame: 6 month

    CFU

Sponsors and collaborators

Lead sponsor

Didem Sakaryali Uyar

Other

Registry information

Official study title

Evaluation of Streptococcus Mutans and Lactobacillus Species Due to Probiotic Use in Oral Flora

Important dates

Study start
2020
Primary completion
2022
Study completion
2022
First posted
May 16, 2023
Registry last updated
May 16, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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