Effects of Platelet and Leukocyte-rich Fibrin on Alveolar Ridge Maintenance Through Three-dimensional Analysis

Understanding, through accurate and reliable volumetric analysis, how the biomaterial (LPRF) and the thickness of the vestibular bone plate influence changes in bone volume after extraction, is essential for making clinical decisions that impact implant-supported rehabilitation.

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Key information

Conditions

Caries Active Dental Caries Mouth Diseases Periodontal Diseases Stomatognathic Diseases Tooth Decay Tooth Demineralization Tooth Diseases Tooth Loss Tooth Loss / Rehabilitation

Age range

21 year–70 year

Sex eligibility

All sexes

Study type

Observational

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

This prospective clinical study was conducted in accordance with the ethical principles outlined in the Declaration of Helsinki and received approval from the Research Ethics Committee of Guarulhos University, São Paulo, Brazil (CEP-UnG #. 515.153). Thirty-nine patients (24 women and 15 men), aged between 22 and 80 years, who were in overall good health, non-diabetic, periodontally healthy, non-smokers, free of blood dyscrasias, not pregnant or lactating, and requiring extraction of non-contiguous, compromised teeth due to root fractures, caries, unsuccessful endodontic treatment, root resorption, or orthodontic reasons, were enrolled.

Treatment and study plan

Alveolar socket preservation with graft and flap surgery

Procedure

teeth to either the control group (coagulant-filled alveoli) or the test group (alveoli filled with platelet-rich fibrin and LPRF leukocytes)

Primary outcomes

bone volume after 16 weeks

Time frame: 16 weeks
aveolar bone contraction

Time frame: 4 months

Sponsors and collaborators

Lead sponsor

University of Guarulhos

Other

Registry information

Official study title

Assessment of the Effects of Platelet and Leukocyte-rich Fibrin on Vestibular Bone Plate Thickness on Alveolar Ridge Maintenance Through Three-dimensional Analysis

Important dates

Study start: 2016
Primary completion: 2018
Study completion: 2022
First posted: Dec 11, 2025
Registry last updated: Dec 18, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed